Asialoglycoprotein Receptor 1 Antibody - #DF14010

(3)  
製品: Asialoglycoprotein Receptor 1 Antibody
カタログ: DF14010
タンパク質の説明: Rabbit polyclonal antibody to Asialoglycoprotein Receptor 1
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
分子量: 33~40kD; 33kD(Calculated).
ユニプロット: P07306

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関連ダウンロード
MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
Asialoglycoprotein Receptor 1 Antibody detects endogenous levels of total Asialoglycoprotein Receptor 1.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

ASGP-R 1; ASGPR 1; ASGPR; ASGPR1; Asgr1; ASGR1_HUMAN; Asialoglycoprotein receptor 1; C type lectin domain family 4 member H1; C-type lectin domain family 4 member H1; CLEC4H1; Hepatic lectin H1; HL-1;

免疫原

免疫原:

A synthesized peptide derived from Human Asialoglycoprotein Receptor 1.

Uniprot:

P07306(ASGR1_HUMAN) >>Visit HPA database.

遺伝子(ID):
ASGR1(432)
発現特異性:
P07306 ASGR1_HUMAN:

Expressed exclusively in hepatic parenchymal cells.

タンパク質配列:
MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL

研究背景

機能:

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

PTMs:

Phosphorylated on a cytoplasmic Ser residue.

細胞の位置付け:

Membrane>Single-pass type II membrane protein.

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed exclusively in hepatic parenchymal cells.

サブユニット構造:

Interacts with LASS2.

(Microbial infection) Interacts with hepatitis E virus capsid protein ORF2.

研究領域

· Organismal Systems > Endocrine system > Thyroid hormone synthesis.

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