GTF2IRD1 Antibody - #DF14018
| 製品: | GTF2IRD1 Antibody |
| カタログ: | DF14018 |
| タンパク質の説明: | Rabbit polyclonal antibody to GTF2IRD1 |
| アプリケーション: | ELISA(peptide) |
| 反応性: | Human |
| 分子量: | 106kD; 106kD(Calculated). |
| ユニプロット: | Q9UHL9 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
免疫原
A synthesized peptide derived from GTF2IRD1.
Highly expressed in adult skeletal muscle, heart, fibroblast, bone and fetal tissues. Expressed at lower levels in all other tissues tested.
- Q9UHL9 GT2D1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALLGKRCDVPTNGCGPDRWNSAFTRKDEIITSLVSALDSMCSALSKLNAEVACVAVHDESAFVVGTEKGRMFLNARKELQSDFLRFCRGPPWKDPEAEHPKKVQRGEGGGRSLPRSSLEHGSDVYLLRKMVEEVFDVLYSEALGRASVVPLPYERLLREPGLLAVQGLPEGLAFRRPAEYDPKALMAILEHSHRIRFKLKRPLEDGGRDSKALVELNGVSLIPKGSRDCGLHGQAPKVPPQDLPPTATSSSMASFLYSTALPNHAIRELKQEAPSCPLAPSDLGLSRPMPEPKATGAQDFSDCCGQKPTGPGGPLIQNVHASKRILFSIVHDKSEKWDAFIKETEDINTLRECVQILFNSRYAEALGLDHMVPVPYRKIACDPEAVEIVGIPDKIPFKRPCTYGVPKLKRILEERHSIHFIIKRMFDERIFTGNKFTKDTTKLEPASPPEDTSAEVSRATVLDLAGNARSDKGSMSEDCGPGTSGELGGLRPIKIEPEDLDIIQVTVPDPSPTSEEMTDSMPGHLPSEDSGYGMEMLTDKGLSEDARPEERPVEDSHGDVIRPLRKQVELLFNTRYAKAIGISEPVKVPYSKFLMHPEELFVVGLPEGISLRRPNCFGIAKLRKILEASNSIQFVIKRPELLTEGVKEPIMDSQGTASSLGFSPPALPPERDSGDPLVDESLKRQGFQENYDARLSRIDIANTLREQVQDLFNKKYGEALGIKYPVQVPYKRIKSNPGSVIIEGLPPGIPFRKPCTFGSQNLERILAVADKIKFTVTRPFQGLIPKPDEDDANRLGEKVILREQVKELFNEKYGEALGLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFAEICNDAKVPAKDSSIPKRKRKRVSEGNSVSSSSSSSSSSSSNPDSVASANQISLVQWPMYMVDYAGLNVQLPGPLNY
PTMs - Q9UHL9 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K94 | Ubiquitination | Uniprot | |
| S113 | Phosphorylation | Uniprot | |
| K130 | Ubiquitination | Uniprot | |
| S193 | Phosphorylation | Uniprot | |
| K201 | Ubiquitination | Uniprot | |
| K212 | Sumoylation | Uniprot | |
| K225 | Sumoylation | Uniprot | |
| K271 | Sumoylation | Uniprot | |
| K271 | Ubiquitination | Uniprot | |
| K308 | Sumoylation | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| S329 | Phosphorylation | Uniprot | |
| K337 | Sumoylation | Uniprot | |
| K337 | Ubiquitination | Uniprot | |
| K379 | Sumoylation | Uniprot | |
| K379 | Ubiquitination | Uniprot | |
| K395 | Ubiquitination | Uniprot | |
| T403 | Phosphorylation | Uniprot | |
| Y404 | Phosphorylation | Uniprot | |
| S418 | Phosphorylation | Uniprot | |
| K436 | Sumoylation | Uniprot | |
| K436 | Ubiquitination | Uniprot | |
| K443 | Sumoylation | Uniprot | |
| K443 | Ubiquitination | Uniprot | |
| S448 | Phosphorylation | Uniprot | |
| T461 | Phosphorylation | Uniprot | |
| S471 | Phosphorylation | Uniprot | |
| S475 | Phosphorylation | Uniprot | |
| S477 | Phosphorylation | Uniprot | |
| K495 | Sumoylation | Uniprot | |
| K567 | Sumoylation | Uniprot | |
| Y577 | Phosphorylation | Uniprot | |
| K579 | Sumoylation | Uniprot | |
| K579 | Ubiquitination | Uniprot | |
| S584 | Phosphorylation | Uniprot | |
| K638 | Sumoylation | Uniprot | |
| S654 | Phosphorylation | Uniprot | |
| K684 | Sumoylation | Uniprot | |
| K684 | Ubiquitination | Uniprot | |
| T704 | Phosphorylation | Uniprot | |
| K715 | Ubiquitination | Uniprot | |
| K716 | Ubiquitination | Uniprot | |
| Y717 | Phosphorylation | Uniprot | |
| K724 | Sumoylation | Uniprot | |
| K724 | Ubiquitination | Uniprot | |
| K754 | Ubiquitination | Uniprot | |
| K787 | Sumoylation | Uniprot | |
| K799 | Ubiquitination | Uniprot | |
| K807 | Ubiquitination | Uniprot | |
| Y814 | Phosphorylation | Uniprot | |
| Y828 | Phosphorylation | Uniprot | |
| K829 | Sumoylation | Uniprot | |
| K829 | Ubiquitination | Uniprot | |
| S834 | Phosphorylation | Uniprot | |
| S906 | Phosphorylation | Uniprot | |
| S914 | Phosphorylation | Uniprot | |
| S915 | Phosphorylation | Uniprot | |
| S916 | Phosphorylation | Uniprot | |
| S917 | Phosphorylation | Uniprot |
研究背景
May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity).
Nucleus.
Highly expressed in adult skeletal muscle, heart, fibroblast, bone and fetal tissues. Expressed at lower levels in all other tissues tested.
Interacts with the retinoblastoma protein (RB1) via its C-terminus.
The N-terminal half may have an activating activity.
Belongs to the TFII-I family.
研究領域
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Genetic Information Processing > Transcription > Basal transcription factors.
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
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