Sprouty 2 Antibody - #DF14109

(1)  
製品: Sprouty 2 Antibody
カタログ: DF14109
タンパク質の説明: Rabbit polyclonal antibody to Sprouty 2
アプリケーション: IF/ICC
反応性: Human, Mouse
分子量: 40kD; 35kD(Calculated).
ユニプロット: O43597

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
クローナリティ:
Polyclonal
特異性:
Sprouty 2 Antibody detects endogenous levels of total Sprouty 2.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

hSPRY 2; hSPRY2; MGC23039; Protein sprouty homolog 2; Sprouty 2; Sprouty homolog 2 (Drosophila); Sprouty homolog 2; Sprouty2; Spry 2; Spry-2; SPRY2; SPY2_HUMAN;

免疫原

免疫原:

A synthesized peptide derived from Human Sprouty 2.

Uniprot:

O43597(SPY2_HUMAN) >>Visit HPA database.

遺伝子(ID):
SPRY2(10253)
タンパク質配列:
MEARAQSGNGSQPLLQTPRDGGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQHSQVHSSARAPLSRSISTVSSGSRSSTRTSTSSSSSEQRLLGSSFSSGPVADGIIRVQPKSELKPGELKPLSKEDLGLHAYRCEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTCVCCVKGLFYHCSNDDEDNCADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCLKLCQGCYDRVNRPGCRCKNSNTVCCKVPTVPPRNFEKPT

研究背景

機能:

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

PTMs:

Cleaved at Pro-144 by the prolyl endopeptidase FAP (seprase) activity (in vitro).

細胞の位置付け:

Cytoplasm>Cytoskeleton. Cell projection>Ruffle membrane.
Note: Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Interacts with RAF1. Part of a tripartite complex containing GAB1, METTL13 and SPRY2. Interacts with METTL13.

タンパク質ファミリー:

The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.

Belongs to the sprouty family.

研究領域

· Human Diseases > Cancers: Overview > MicroRNAs in cancer.

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