FBXL3 Antibody - #DF14145
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
F box and leucine rich repeat protein 3; F box and leucine rich repeat protein 3A; F box protein Fbl3a; F-box and leucine-rich repeat protein 3A; F-box/LRR-repeat protein 3; F-box/LRR-repeat protein 3A; FBL3; FBL3A; Fbxl3; FBXL3_HUMAN; FBXL3A;
免疫原
A synthesized peptide derived from Human FBXL3.
- Q9UKT7 FBXL3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKRGGRDSDRNSSEEGTAEKSKKLRTTNEHSQTCDWGNLLQDIILQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIRHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW
研究背景
Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex.
Undergoes autophagy-mediated degradation in the liver in a time-dependent manner.
Nucleus. Cytoplasm.
Note: Predominantly nuclear.
Widely expressed.
Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL3) composed of CUL1, SKP1, RBX1 and FBXL3 (By similarity). Interacts with CRY1 and CRY2 (phosphorylated). Interacts with HDAC3 (By similarity). Interacts with KDM8 (By similarity).
研究領域
· Organismal Systems > Environmental adaptation > Circadian rhythm. (View pathway)
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