SENP1 Antibody - #AF0275
(2)
(9)
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF0275, RRID:AB_2833445.
折りたたみ／展開
SENP 1; SENP1; SENP1_HUMAN; Sentrin specific protease 1; Sentrin-specific protease 1; Sentrin/SUMO specific protease 1; Sentrin/SUMO specific protease; Sentrin/SUMO specific protease SENP 1; Sentrin/SUMO specific protease SENP1; Sentrin/SUMO-specific protease SENP1; SUMO1/sentrin specific peptidase 1; SUMO1/sentrin specific protease 1; SuPr 2; SuPr2;
免疫原
Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.
- Q9P0U3 SENP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9P0U3 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S57 | Phosphorylation | Uniprot | |
| T59 | Phosphorylation | Uniprot | |
| S78 | Phosphorylation | Uniprot | |
| S80 | Phosphorylation | Uniprot | |
| T102 | Phosphorylation | Uniprot | |
| K111 | Ubiquitination | Uniprot | |
| S117 | Phosphorylation | Uniprot | |
| K124 | Methylation | Uniprot | |
| K124 | Ubiquitination | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| S130 | Phosphorylation | Uniprot | |
| S132 | Phosphorylation | Uniprot | |
| K136 | Methylation | Uniprot | |
| K136 | Ubiquitination | Uniprot | |
| S149 | Phosphorylation | Uniprot | |
| K153 | Ubiquitination | Uniprot | |
| S157 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| S161 | Phosphorylation | Uniprot | |
| S167 | Phosphorylation | Uniprot | |
| S170 | Phosphorylation | Uniprot | |
| S180 | Phosphorylation | Uniprot | |
| K210 | Ubiquitination | Uniprot | |
| S224 | Phosphorylation | Uniprot | |
| S226 | Phosphorylation | Uniprot | |
| K227 | Ubiquitination | Uniprot | |
| K231 | Ubiquitination | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| T328 | Phosphorylation | Uniprot | |
| T330 | Phosphorylation | Uniprot | |
| Y349 | Phosphorylation | Uniprot | |
| K364 | Acetylation | Uniprot | |
| K364 | Ubiquitination | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| K396 | Acetylation | Uniprot | |
| K396 | Ubiquitination | Uniprot | |
| T414 | Phosphorylation | Uniprot | |
| S416 | Phosphorylation | Uniprot | |
| K429 | Acetylation | Uniprot | |
| K429 | Ubiquitination | Uniprot | |
| K432 | Ubiquitination | Uniprot | |
| K502 | Ubiquitination | Uniprot | |
| K510 | Ubiquitination | Uniprot | |
| K577 | Ubiquitination | Uniprot | |
| K609 | Ubiquitination | Uniprot | |
| K616 | Ubiquitination | Uniprot |
研究背景
Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Deconjugates SUMO1 from METTL3. Desumoylates CCAR2 which decreases its interaction with SIRT1. Deconjugates SUMO1 from GPS2.
Nucleus. Cytoplasm.
Note: Shuttles between cytoplasm and nucleus.
Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.
Interacts with MTA1. Interacts with CCAR2 (via N-terminus).
Belongs to the peptidase C48 family.
参考文献
Application: WB Species: Mouse Sample:
Application: WB Species: mouse Sample: Liver sinusoidal endothelial cells (LSECs)
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