DNase I Antibody - #DF14243

(2)  
製品: DNase I Antibody
カタログ: DF14243
タンパク質の説明: Rabbit polyclonal antibody to DNase I
アプリケーション: ELISA(peptide)
反応性: Human, Mouse, Rat
分子量: 30~40kD; 31kD(Calculated).
ユニプロット: P24855

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
DNase I Antibody detects endogenous levels of total DNase I.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Deoxyribonuclease 1; Deoxyribonuclease I; Deoxyribonuclease-1; Deoxyribonuclease1; DeoxyribonucleaseI; DNAS1_HUMAN; DNASE 1; DNase I; DNase I lysosomal; DNASE1; DNaseI; DNL 1; DNL1; Dornase alfa; DRNI; FLJ38093; Human urine deoxyribonuclease I;

免疫原

免疫原:

A synthesized peptide derived from Human DNase I.

Uniprot:

P24855(DNAS1_HUMAN) >>Visit HPA database.

遺伝子(ID):
DNASE1(1773)
発現特異性:
P24855 DNAS1_HUMAN:

Principally in tissues of the digestive system. Highest levels found in urine, but also relatively abundant in semen and saliva.

タンパク質配列:
MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQEVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYDDGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKWGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK

研究背景

機能:

Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).

細胞の位置付け:

Secreted. Nucleus envelope.
Note: Secretory protein, stored in zymogen granules and found in the nuclear envelope.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Principally in tissues of the digestive system. Highest levels found in urine, but also relatively abundant in semen and saliva.

タンパク質ファミリー:

Belongs to the DNase I family.

参考文献

1). Multistage Cooperative Nanodrug Combined with PD‐L1 for Enhancing Antitumor Chemoimmunotherapy. Advanced Healthcare Materials, 2021 (PubMed: 34382363) [IF=10.0]
2). Self-Assembled Immunostimulatory Nanodrug Combined with PD-L1 for Boosting Anti-Tumor Chemoimmunotherapy. , 2022

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