製品: SENP5 Antibody
カタログ: AF0276
タンパク質の説明: Rabbit polyclonal antibody to SENP5
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Monkey
予測: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 86kDa; 87kD(Calculated).
ユニプロット: Q96HI0
RRID: AB_2833446

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 100ul $280 在庫あり
 200ul $350 在庫あり

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Monkey
予測:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(91%), Xenopus(91%)
クローナリティ:
Polyclonal
特異性:
SENP5 Antibody detects endogenous levels of total SENP5.
RRID:
AB_2833446
引用形式: Affinity Biosciences Cat# AF0276, RRID:AB_2833446.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

FKSG45; FLJ42398; MGC27076; Protease FKSG45; SENP5; SENP5_HUMAN; Sentrin specific protease SENP5; Sentrin-specific protease 5; Sentrin/SUMO specific protease SENP5; Sentrin/SUMO-specific protease SENP5; SUMO specific protease SENP5; SUMO1/sentrin specific peptidase 5; SUMO1/sentrin specific protease 5;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
タンパク質の説明:
SENP5 Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates.
タンパク質配列:
MKKQRKILWRKGIHLAFSEKWNTGFGGFKKFYFHQHLCILKAKLGRPVTWNRQLRHFQGRKKALQIQKTWIKDEPLCAKTKFNVATQNVSTLSSKVKRKDAKHFISSSKTLLRLQAEKLLSSAKNSDHEYCREKNLLKAVTDFPSNSALGQANGHRPRTDPQPSDFPMKFNGESQSPGESGTIVVTLNNHKRKGFCYGCCQGPEHHRNGGPLIPKKFQLNQHRRIKLSPLMMYEKLSMIRFRYRILRSQHFRTKSKVCKLRKAQRSWVQKVTGDHQETRRENGEGGSCSPFPSPEPKDPSCRHQPYFPDMDSSAVVKGTNSHVPDCHTKGSSFLGKELSLDEAFPDQQNGSATNAWDQSSCSSPKWECTELIHDIPLPEHRSNTMFISETEREIMTLGQENQTSSVSDDRVKLSVSGADTSVSSVDGPVSQKAVQNENSYQMEEDGSLKQSILSSELLDHPYCKSPLEAPLVCSGLKLENQVGGGKNSQKASPVDDEQLSVCLSGFLDEVMKKYGSLVPLSEKEVLGRLKDVFNEDFSNRKPFINREITNYRARHQKCNFRIFYNKHMLDMDDLATLDGQNWLNDQVINMYGELIMDAVPDKVHFFNSFFHRQLVTKGYNGVKRWTKKVDLFKKSLLLIPIHLEVHWSLITVTLSNRIISFYDSQGIHFKFCVENIRKYLLTEAREKNRPEFLQGWQTAVTKCIPQQKNDSDCGVFVLQYCKCLALEQPFQFSQEDMPRVRKRIYKELCECRLMD

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Xenopus
91
Chicken
91
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q96HI0 基板として

Site PTM Type Enzyme
K3 Acetylation
K6 Acetylation
K11 Acetylation
K62 Ubiquitination
K72 Ubiquitination
S106 Phosphorylation
S107 Phosphorylation
K109 Ubiquitination
S176 Phosphorylation
K216 Ubiquitination
Y243 Phosphorylation
K270 Ubiquitination
S287 Phosphorylation
S289 Phosphorylation
S293 Phosphorylation
S332 Phosphorylation
S421 Phosphorylation
S423 Phosphorylation
S424 Phosphorylation
S439 Phosphorylation
K449 Ubiquitination
S465 Phosphorylation
K477 Ubiquitination
K486 Ubiquitination
K513 Ubiquitination
K523 Ubiquitination
K530 Ubiquitination
T651 Phosphorylation
Y679 Phosphorylation
T682 Phosphorylation
K687 Ubiquitination
K746 Ubiquitination

研究背景

機能:

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.

細胞の位置付け:

Nucleus>Nucleolus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Interacts with CCAR2.

タンパク質ファミリー:

Belongs to the peptidase C48 family.

Restrictive clause

 

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