TP53INP2 Antibody - #DF14312

(1)   (2)  
製品: TP53INP2 Antibody
カタログ: DF14312
タンパク質の説明: Rabbit polyclonal antibody to TP53INP2
アプリケーション: WB IF/ICC
反応性: Human, Mouse, Rat
分子量: 24kD(Calculated).
ユニプロット: Q8IXH6

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IHC Protocol
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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
TP53INP2 Antibody detects endogenous levels of total TP53INP2.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

C20orf110; Diabetes and obesity regulated; p53 inducible protein U; DOR; p53-inducible protein U; PIG-U; PINH; T53I2_HUMAN; Tp53inp2; Tumor protein p53-inducible nuclear protein 2;

免疫原

免疫原:

A synthesized peptide derived from Human TP53INP2.

Uniprot:

Q8IXH6(T53I2_HUMAN) >>Visit HPA database.

遺伝子(ID):
TP53INP2(58476)
タンパク質配列:
MFQRLSSLFFSTPSPPEDPDCPRAFVSEEDEVDGWLIIDLPDSYAAPPSPGAAPAPAGRPPPAPSLMDESWFVTPPACFTAEGPGLGPARLQSSPLEDLLIEHPSMSVYVTGSTIVLEPGSPSPLPDAALPDGDLSEGELTPARREPRAARHAAPLPARAALLEKAGQVRRLQRARQRAERHALSAKAVQRQNRARESRPRRSKNQSSFIYQPCQRQFNY

研究背景

機能:

Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.

細胞の位置付け:

Cytoplasm>Cytosol. Nucleus. Nucleus>PML body. Cytoplasmic vesicle>Autophagosome.
Note: Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Interacts with VMP1, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, MAP1LC3C and THRA.

タンパク質ファミリー:

The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.

研究領域

· Cellular Processes > Transport and catabolism > Autophagy - animal.   (View pathway)

参考文献

1). TP53INP2 knockdown inhibits inflammatory response and apoptosis after spinal cord injury. Immunity, inflammation and disease, 2024 (PubMed: 38652010) [IF=3.2]

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