CMPK2 Antibody - #DF14326

(2)  
製品: CMPK2 Antibody
カタログ: DF14326
タンパク質の説明: Rabbit polyclonal antibody to CMPK2
アプリケーション: IHC IF/ICC
反応性: Human
分子量: 49kD(Calculated).
ユニプロット: Q5EBM0

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Polyclonal
特異性:
CMPK2 Antibody detects endogenous levels of total CMPK2.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

1200004E04Rik; Cmpk2; CMPK2_HUMAN; Cytidine monophosphate (UMP CMP) kinase 2, mitochondrial; mitochondrial; Mitochondrial UMP CMP kinase; OTTHUMP00000200305; Thymidine monophosphate kinase 2; TMPK2; TYKi; UMP CMP kinase 2, mitochondrial; UMP CMP kinase 2, mitochondrial; cytidylate kinase 2; UMP CMPK2; UMP-CMP kinase 2;

免疫原

免疫原:

A synthesized peptide derived from Human CMPK2.

Uniprot:

Q5EBM0(CMPK2_HUMAN) >>Visit HPA database.

遺伝子(ID):
CMPK2(129607)
発現特異性:
Q5EBM0 CMPK2_HUMAN:

Among all investigated tumors, leukemia cells show the most abundant expression.

タンパク質配列:
MAFARRLLRGPLSGPLLGRRGVCAGAMAPPRRFVLELPDCTLAHFALGADAPGDADAPDPRLAALLGPPERSYSLCVPVTPDAGCGARVRAARLHQRLLHQLRRGPFQRCQLLRLLCYCPGGQAGGAQQGFLLRDPLDDPDTRQALLELLGACQEAPRPHLGEFEADPRGQLWQRLWEVQDGRRLQVGCAQVVPVPEPPLHPVVPDLPSSVVFPDREAARAVLEECTSFIPEARAVLDLVDQCPKQIQKGKFQVVAIEGLDATGKTTVTQSVADSLKAVLLKSPPSCIGQWRKIFDDEPTIIRRAFYSLGNYIVASEIAKESAKSPVIVDRYWHSTATYAIATEVSGGLQHLPPAHHPVYQWPEDLLKPDLILLLTVSPEERLQRLQGRGMEKTREEAELEANSVFRQKVEMSYQRMENPGCHVVDASPSREKVLQTVLSLIQNSFSEP

研究背景

機能:

May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity.

細胞の位置付け:

Mitochondrion.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Among all investigated tumors, leukemia cells show the most abundant expression.

タンパク質ファミリー:

Belongs to the thymidylate kinase family.

研究領域

· Metabolism > Nucleotide metabolism > Pyrimidine metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

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