C15orf38 Antibody - #DF14443

(2)  
製品: C15orf38 Antibody
カタログ: DF14443
タンパク質の説明: Rabbit polyclonal antibody to C15orf38
アプリケーション: IHC IF/ICC
反応性: Human, Mouse
分子量: 25kD(Calculated).
ユニプロット: Q7Z6K5

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
クローナリティ:
Polyclonal
特異性:
C15orf38 Antibody detects endogenous levels of total C15orf38.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

2610034B18Rik; Actin related protein 2/3 complex inhibitor; Arp2/3 inhibition protein; ARPIN; C15orf38; Chromosome 15 open reading frame 38; CO038_HUMAN; Hypothetical protein LOC348110; MGC61550; RIKEN cDNA 2610034B18; UPF0552 protein C15orf38;

免疫原

免疫原:

A synthesized peptide derived from Human C15orf38.

Uniprot:

Q7Z6K5(ARPIN_HUMAN) >>Visit HPA database.

遺伝子(ID):
ARPIN(348110)
タンパク質配列:
MSRIYHDGALRNKAVQSVRLPGAWDPAAHQGGNGVLLEGELIDVSRHSILDTHGRKERYYVLYIRPSHIHRRKFDAKGNEIEPNFSATRKVNTGFLMSSYKVEAKGDTDRLTPEALKGLVNKPELLALTESLTPDHTVAFWMPESEMEVMELELGAGVRLKTRGDGPFLDSLAKLEAGTVTKCNFTGDGKTGASWTDNIMAQKCSKGAAAEIREQGDGAEDEEWDD

研究背景

機能:

Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.

細胞の位置付け:

Cell projection>Lamellipodium.
Note: Colocalized with the WAVE complex at lamelliupodium tip.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Associates with the Arp2/3 complex. Interacts with ARPC2; enhanced by activated RAC1. Interacts with ARPC5; the interaction is dependent on RAC1.

タンパク質ファミリー:

The acidic C-terminus is necessary and sufficient to inhibit ARP2/3 complex activity.

Belongs to the Arpin family.

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