AFfirm™ HO-1 Mouse Monoclonal Antibody - #BF8020
(1)
(3)
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
32 kD; bK286B10; D8Wsu38e; heat shock protein 32 kD; heat shock protein 32kD; Heat shock protein; Heme oxygenase (decycling) 1; Heme oxygenase 1; Hemox; HMOX 1; Hmox; Hmox1; HMOX1_HUMAN; HO 1; HO; HO-1; HO1; Hsp32;
免疫原
A synthesized peptide derived from human HO-1.
Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
- P09601 HMOX1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRASNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM
PTMs - P09601 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K18 | Acetylation | Uniprot | |
| K18 | Ubiquitination | Uniprot | |
| K22 | Ubiquitination | Uniprot | |
| K39 | Acetylation | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| S53 | Phosphorylation | Uniprot | |
| Y55 | Phosphorylation | Uniprot | |
| Y58 | Phosphorylation | Uniprot | |
| K69 | Ubiquitination | Uniprot | |
| K86 | Ubiquitination | Uniprot | |
| T108 | Phosphorylation | Uniprot | |
| Y114 | Phosphorylation | Uniprot | |
| Y137 | Phosphorylation | Uniprot | |
| K148 | Ubiquitination | Uniprot | |
| K149 | Ubiquitination | Uniprot | |
| K153 | Ubiquitination | Uniprot | |
| S160 | Phosphorylation | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| S188 | Phosphorylation | P31749 (AKT1) | Uniprot |
| T192 | Phosphorylation | Uniprot | |
| S229 | Phosphorylation | Uniprot | |
| S231 | Phosphorylation | Uniprot | |
| K243 | Acetylation | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| T252 | Phosphorylation | Uniprot | |
| K256 | Acetylation | Uniprot | |
| K256 | Ubiquitination | Uniprot | |
| Y286 | Phosphorylation | Uniprot |
研究背景
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
Microsome. Endoplasmic reticulum membrane>Peripheral membrane protein>Cytoplasmic side.
Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
Belongs to the heme oxygenase family.
研究領域
· Cellular Processes > Cell growth and death > Ferroptosis. (View pathway)
· Environmental Information Processing > Signal transduction > HIF-1 signaling pathway. (View pathway)
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Overview > MicroRNAs in cancer.
· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma. (View pathway)
· Metabolism > Metabolism of cofactors and vitamins > Porphyrin and chlorophyll metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Digestive system > Mineral absorption.
参考文献
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