TTC5 Antibody - #DF14538
| 製品: | TTC5 Antibody |
| カタログ: | DF14538 |
| タンパク質の説明: | Rabbit polyclonal antibody to TTC5 |
| アプリケーション: | ELISA(peptide) |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 49kD(Calculated). |
| ユニプロット: | Q8N0Z6 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
Strap; Stress-responsive activator of p300; Tetratricopeptide repeat domain 5; TPR repeat protein 5;
免疫原
A synthesized peptide derived from human TTC5.
- Q8N0Z6 TTC5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMADEEEEVKPILQKLQELVDQLYSFRDCYFETHSVEDAGRKQQDVQKEMEKTLQQMEEVVGSVQGKAQVLMLTGKALNVTPDYSPKAEELLSKAVKLEPELVEAWNQLGEVYWKKGDVAAAHTCFSGALTHCRNKVSLQNLSMVLRQLRTDTEDEHSHHVMDSVRQAKLAVQMDVHDGRSWYILGNSYLSLYFSTGQNPKISQQALSAYAQAEKVDRKASSNPDLHLNRATLHKYEESYGEALEGFSRAAALDPAWPEPRQREQQLLEFLDRLTSLLESKGKVKTKKLQSMLGSLRPAHLGPCSDGHYQSASGQKVTLELKPLSTLQPGVNSGAVILGKVVFSLTTEEKVPFTFGLVDSDGPCYAVMVYNIVQSWGVLIGDSVAIPEPNLRLHRIQHKGKDYSFSSVRVETPLLLVVNGKPQGSSSQAVATVASRPQCE
研究背景
Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).
Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300.
Nucleus. Cytoplasm.
Note: Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm.
Interacts with JMY and p300/EP300.
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