DKK4 Antibody - #DF14554
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
Dickkopf 4; Dickkopf gene 4; Dickkopf homolog 4 (Xenopus laevis); Dickkopf homolog 4; Dickkopf related protein 4; Dickkopf-4; Dickkopf-related protein 4 short form; Dickkopf4; DKK 4; Dkk-4; DKK4; DKK4_HUMAN; hDkk 4; hDkk-4; hDkk4; MGC129562; MGC129563;
免疫原
A synthesized peptide derived from human DKK4.
- Q9UBT3 DKK4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVAAVLLGLSWLCSPLGALVLDFNNIRSSADLHGARKGSQCLSDTDCNTRKFCLQPRDEKPFCATCRGLRRRCQRDAMCCPGTLCVNDVCTTMEDATPILERQLDEQDGTHAEGTTGHPVQENQPKRKPSIKKSQGRKGQEGESCLRTFDCGPGLCCARHFWTKICKPVLLEGQVCSRRGHKDTAQAPEIFQRCDCGPGLLCRSQLTSNRQHARLRVCQKIEKL
研究背景
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Appears to be not glycosylated.
Can be proteolytically processed by a furin-like protease.
Secreted.
Expressed in cerebellum, T-cells, esophagus and lung.
Interacts with LRP5 and LRP6.
The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
Belongs to the dickkopf family.
研究領域
· Environmental Information Processing > Signal transduction > Wnt signaling pathway. (View pathway)
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