VSIG4 Antibody - #DF14591

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製品: VSIG4 Antibody
カタログ: DF14591
タンパク質の説明: Rabbit polyclonal antibody to VSIG4
アプリケーション: WB IHC IF/ICC
反応性: Human, Rat
分子量: 40/50kD; 44kD(Calculated).
ユニプロット: Q9Y279

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Rat
クローナリティ:
Polyclonal
特異性:
VSIG4 Antibody detects endogenous levels of VSIG4.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Complement receptor of the immunoglobulin superfamily; CRIg; Ig superfamily protein; Protein Z39Ig; UNQ317/PRO362; V set and immunoglobulin domain containing 4; V-set and immunoglobulin domain-containing protein 4; VSIG4; VSIG4_HUMAN; Z39IG;

免疫原

免疫原:

A synthesized peptide derived from human VSIG4.

Uniprot:

Q9Y279(VSIG4_HUMAN) >>Visit HPA database.

遺伝子(ID):
VSIG4(11326)
発現特異性:
Q9Y279 VSIG4_HUMAN:

Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and placenta. Expressed in resting macrophages.

タンパク質配列:
MGILLGLLLLGHLTVDTYGRPILEVPESVTGPWKGDVNLPCTYDPLQGYTQVLVKWLVQRGSDPVTIFLRDSSGDHIQQAKYQGRLHVSHKVPGDVSLQLSTLEMDDRSHYTCEVTWQTPDGNQVVRDKITELRVQKLSVSKPTVTTGSGYGFTVPQGMRISLQCQARGSPPISYIWYKQQTNNQEPIKVATLSTLLFKPAVIADSGSYFCTAKGQVGSEQHSDIVKFVVKDSSKLLKTKTEAPTTMTYPLKATSTVKQSWDWTTDMDGYLGETSAGPGKSLPVFAIILIISLCCMVVFTMAYIMLCRKTSQQEHVYEAARAHAREANDSGETMRVAIFASGCSSDEPTSQNLGNNYSDEPCIGQEYQIIAQINGNYARLLDTVPLDYEFLATEGKSVC

研究背景

機能:

Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.

細胞の位置付け:

Membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and placenta. Expressed in resting macrophages.

研究領域

· Organismal Systems > Immune system > Complement and coagulation cascades.   (View pathway)

参考文献

1). Exploring the immune microenvironment of osteosarcoma through T cell exhaustion-associated gene expression: a study on prognosis prediction. Frontiers in immunology, 2023 (PubMed: 38169731) [IF=7.3]

Application: IHC    Species: Human    Sample:

Figure 12 Validation of the prognostic model using the H-score obtained by immunohistochemistry (IHC). (A) Osteosarcoma patients were categorized into low and high-risk groups based on the immunohistochemistry (IHC) results of PLEKHO2, VSIG4, MPP1, and GBP2. (B) The high-risk group exhibited a poorer survival outcome compared to the low-risk group. (C) Time-dependent ROC curves were generated in the IHC validation cohort, with AUC values of 0.800 at 1 year, 0.722 at 3 years, and 0.654 at 5 years. (D, E) The distribution of risk scores, the survival status of each patient, and a heatmap depicting the prognostic 4-gene signature were analyzed in the IHC validation cohort.

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