PTPMT1 Antibody - #DF14604
| 製品: | PTPMT1 Antibody |
| カタログ: | DF14604 |
| タンパク質の説明: | Rabbit polyclonal antibody to PTPMT1 |
| アプリケーション: | ELISA(peptide) |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 23kD(Calculated). |
| ユニプロット: | Q8WUK0 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
DUSP23; FLJ46081; MOSP; NB4 apoptosis/differentiation related protein; Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; Phosphoinositide lipid phosphatase; PLIP; PNAS 129; protein tyrosine phosphatase mitochondrial 1; Protein-tyrosine phosphatase mitochondrial 1; pten like phosphatase; PTEN-like phosphatase; PTPM1_HUMAN; Ptpmt1;
免疫原
A synthesized peptide derived from human PTPMT1.
- Q8WUK0 PTPM1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAATALLEAGLARVLFYPTLLYTLFRGKVPGRAHRDWYHRIDPTVLLGALPLRSLTRQLVQDENVRGVITMNEEYETRFLCNSSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQITARATKDGTFVISKT
研究背景
Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity). Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity.
Mitochondrion inner membrane>Peripheral membrane protein>Matrix side.
Interacts with STYXL1; the interaction inhibits PTPMT1 catalytic activity.
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
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