RAMP3 Antibody - #DF14693

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製品: RAMP3 Antibody
カタログ: DF14693
タンパク質の説明: Rabbit polyclonal antibody to RAMP3
アプリケーション: IF/ICC
反応性: Human, Mouse, Rat
分子量: 17kD(Calculated).
ユニプロット: O60896

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MS Report
HPLC Report
MSDS
説明書
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IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
RAMP3 Antibody detects endogenous levels of RAMP3.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Calcitonin receptor like receptor activity modifying protein 3; CRLR activity modifying protein 3; CRLR activity-modifying protein 3; OTTHUMP00000159549; OTTHUMP00000214279; OTTHUMP00000214280; Receptor (calcitonin) activity modifying protein 3; Receptor (G protein-coupled) activity modifying protein 3; Receptor activity modifying protein 3;

免疫原

免疫原:

A synthesized peptide derived from human RAMP3.

Uniprot:

O60896(RAMP3_HUMAN) >>Visit HPA database.

遺伝子(ID):
RAMP3(10268)
発現特異性:
O60896 RAMP3_HUMAN:

Strongly expressed in lung, breast, immune system and fetal tissues.

タンパク質配列:
METGALRRPQLLPLLLLLCGGCPRAGGCNETGMLERLPLCGKAFADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEVLIPLIVIPVVLTVAMAGLVVWRSKRTDTLL

研究背景

機能:

Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

細胞の位置付け:

Cell membrane>Single-pass type I membrane protein. Membrane>Single-pass type I membrane protein.
Note: Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Strongly expressed in lung, breast, immune system and fetal tissues.

サブユニット構造:

Heterodimer of CALCRL and RAMP3 (By similarity). Interacts with GPER1.

タンパク質ファミリー:

Belongs to the RAMP family.

研究領域

· Organismal Systems > Circulatory system > Vascular smooth muscle contraction.   (View pathway)

参考文献

1). Adrenomedullin ameliorates palmitic acid-induced insulin resistance through PI3K/Akt pathway in adipocytes. ACTA DIABETOLOGICA, 2022 (PubMed: 34978596) [IF=3.8]

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