ULBP1 Antibody - #DF14795

(1)  
製品: ULBP1 Antibody
カタログ: DF14795
タンパク質の説明: Rabbit polyclonal antibody to ULBP1
アプリケーション: IHC
反応性: Human
分子量: 28kD(Calculated).
ユニプロット: Q9BZM6

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 100ul $280 在庫あり
 200ul $350 在庫あり

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Polyclonal
特異性:
ULBP1 Antibody detects endogenous levels of ULBP1.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Alcan beta; ALCAN-beta; N2DL-1; N2DL1; N2DL1_HUMAN; NKG2D ligand 1; NKG2D ligand 1 precursor; NKG2DL1; RAET1I; Retinoic acid early transcript 1I; UL16; UL16 binding protein 1; UL16-binding protein 1; ULBP1;

免疫原

免疫原:

A synthesized peptide derived from human ULBP1.

Uniprot:

Q9BZM6(ULBP1_HUMAN) >>Visit HPA database.

遺伝子(ID):
ULBP1(80329)
発現特異性:
Q9BZM6 ULBP1_HUMAN:

Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.

タンパク質配列:
MAAAASPAFLLCLPLLHLLSGWSRAGWVDTHCLCYDFIITPKSRPEPQWCEVQGLVDERPFLHYDCVNHKAKAFASLGKKVNVTKTWEEQTETLRDVVDFLKGQLLDIQVENLIPIEPLTLQARMSCEHEAHGHGRGSWQFLFNGQKFLLFDSNNRKWTALHPGAKKMTEKWEKNRDVTMFFQKISLGDCKMWLEEFLMYWEQMLDPTKPPSLAPGTTQPKAMATTLSPWSLLIIFLCFILAGR

研究背景

機能:

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

細胞の位置付け:

Cell membrane>Lipid-anchor. Endoplasmic reticulum.
Note: In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.

サブユニット構造:

Interacts with KLRK1/NKG2D. Does not bind to beta2-microglobulin.

(Microbial infection) In CMV-infected cells, interacts with the viral glycoprotein UL16; this interaction causes ULBP1 retention in the endoplasmic reticulum and cis-Golgi and prevents binding to and activation of KLRK1/NKG2D, providing CMV with an immune evasion mechanism.

タンパク質ファミリー:

Belongs to the MHC class I family.

研究領域

· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity.   (View pathway)

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