PYCR2 Antibody - #DF15414
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
1810018M05Rik; FLJ54750; Leftb; OTTHUMP00000035614; P5C reductase 2; P5CR 2; P5CR2; P5CR2_HUMAN; PYCR 2; PYCR2; Pyrroline 5 carboxylate reductase 2; Pyrroline 5 carboxylate reductase family member 2; Pyrroline 5 carboxylate reductase isoform; Pyrroline-5-carboxylate reductase 2; RP4-559A3.4;
免疫原
A synthesized peptide derived from human PYCR2.
Detected in erythrocytes (at protein level) (PubMed:2722838, PubMed:6894153). Expressed in fetal brain (PubMed:25865492).
- Q96C36 P5CR2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETVKHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRCMTNTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAYAFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVSTLTPSSPGKLLTRSLALGGKKD
研究背景
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH. Involved in cellular response to oxidative stress.
Cytoplasm. Mitochondrion.
Detected in erythrocytes (at protein level). Expressed in fetal brain.
Homodecamer; composed of 5 homodimers (Probable). Interacts with LTO1.
Belongs to the pyrroline-5-carboxylate reductase family.
研究領域
· Metabolism > Amino acid metabolism > Arginine and proline metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Biosynthesis of amino acids.
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