TMBIM6 Antibody - #DF15555

(3)  
製品: TMBIM6 Antibody
カタログ: DF15555
タンパク質の説明: Rabbit polyclonal antibody to TMBIM6
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
分子量: 30kD; 27kD(Calculated).
ユニプロット: P55061

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関連ダウンロード
MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
IF/ICC 1:100-1:500, IHC 1:50-1:200, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
TMBIM6 Antibody detects endogenous levels of TMBIM6.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Bax inhibitor 1; BI 1; BI-1; BI1; BI1_HUMAN; TEGT; testis enhanced gene transcript (BAX inhibitor 1); Testis enhanced gene transcript; Testis-enhanced gene transcript protein; TMBIM 6; TMBIM6; Transmembrane BAX inhibitor motif containing 6; Transmembrane BAX inhibitor motif containing protein 6; Transmembrane BAX inhibitor motif-containing protein 6;

免疫原

免疫原:

A synthesized peptide derived from human TMBIM6.

Uniprot:

P55061(BI1_HUMAN) >>Visit HPA database.

遺伝子(ID):
TMBIM6(7009)
発現特異性:
P55061 BI1_HUMAN:

Highly abundant in testis.

タンパク質配列:
MNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMFVAAAGAYVHMVTHFIQAGLLSALGSLILMIWLMATPHSHETEQKRLGLLAGFAFLTGVGLGPALEFCIAVNPSILPTAFMGTAMIFTCFTLSALYARRRSYLFLGGILMSALSLLLLSSLGNVFFGSIWLFQANLYVGLVVMCGFVLFDTQLIIEKAEHGDQDYIWHCIDLFLDFITVFRKLMMILAMNEKDKKKEKK

研究背景

機能:

Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).

細胞の位置付け:

Endoplasmic reticulum membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Highly abundant in testis.

サブユニット構造:

Interacts with BCL2 and BCL2L1.

タンパク質ファミリー:

The intra-membrane loop at the C-terminus acts as a calcium pore, mediating calcium leak from the ER into the cytosol.

Belongs to the BI1 family.

Restrictive clause

 

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