F2RL2 Antibody - #DF15686
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製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
coagulation factor II (thrombin) receptor-like 2; Coagulation factor II receptor-like 2; F2RL2; PAR 3; PAR-3; PAR3; PAR3_HUMAN; protease activated receptor 3; Proteinase-activated receptor 3; thrombin receptor like 2; Thrombin receptor-like 2;
免疫原
A synthesized peptide derived from human F2RL2.
Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut.
- O00254 PAR3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKALIFAAAGLLLLLPTFCQSGMENDTNNLAKPTLPIKTFRGAPPNSFEEFPFSALEGWTGATITVKIKCPEESASHLHVKNATMGYLTSSLSTKLIPAIYLLVFVVGVPANAVTLWMLFFRTRSICTTVFYTNLAIADFLFCVTLPFKIAYHLNGNNWVFGEVLCRATTVIFYGNMYCSILLLACISINRYLAIVHPFTYRGLPKHTYALVTCGLVWATVFLYMLPFFILKQEYYLVQPDITTCHDVHNTCESSSPFQLYYFISLAFFGFLIPFVLIIYCYAAIIRTLNAYDHRWLWYVKASLLILVIFTICFAPSNIILIIHHANYYYNNTDGLYFIYLIALCLGSLNSCLDPFLYFLMSKTRNHSTAYLTK
研究背景
Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.
A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
Cell membrane>Multi-pass membrane protein.
Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut.
Interacts with INSC/inscuteable and probably GPSM2.
Belongs to the G-protein coupled receptor 1 family.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Organismal Systems > Immune system > Complement and coagulation cascades. (View pathway)
参考文献
Application: IF/ICC Species: Human Sample: esophageal squamous cell carcinoma (ESCC)
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