KATNAL1 Antibody - #DF15842

製品: KATNAL1 Antibody
カタログ: DF15842
タンパク質の説明: Rabbit polyclonal antibody to KATNAL1
アプリケーション: ELISA(peptide)
反応性: Human, Mouse, Rat
分子量: 55kD(Calculated).
ユニプロット: Q9BW62

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
KATNAL1 Antibody detects endogenous levels of KATNAL1.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Katanin p60 ATPase containing subunit A like 1; Katanin p60 ATPase-containing subunit A-like 1; Katanin p60 subunit A like 1; Katanin p60 subunit A-like 1; KATL1_HUMAN; KATNAL1; MGC2599; OTTHUMP00000018194; OTTHUMP00000042415; OTTHUMP00000061637; p60 katanin like 1; p60 katanin-like 1;

免疫原

免疫原:

A synthesized peptide derived from human KATNAL1.

Uniprot:

Q9BW62(KATL1_HUMAN) >>Visit HPA database.

遺伝子(ID):
KATNAL1(84056)
発現特異性:
Q9BW62 KATL1_HUMAN:

Expressed in testis, restricted to Sertoli cells (at protein level).

タンパク質配列:
MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQVRQELLEEYEQVKSIVSTLESFKIDKPPDFPVSCQDEPFRDPAVWPPPVPAEHRAPPQIRRPNREVRPLRKEMAGVGARGPVGRAHPISKSEKPSTSRDKDYRARGRDDKGRKNMQDGASDGEMPKFDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKWMVEFGSA

研究背景

機能:

Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro.

細胞の位置付け:

Cytoplasm>Cytoskeleton. Cytoplasm. Cytoplasm>Cytoskeleton>Spindle pole. Cytoplasm>Cytoskeleton>Spindle.
Note: Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells (By similarity). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (PubMed:26929214).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in testis, restricted to Sertoli cells (at protein level).

サブユニット構造:

Interacts with KATNB1 and KATNBL1.

タンパク質ファミリー:

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.

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