製品: ADSSL1 Antibody
カタログ: DF15920
タンパク質の説明: Rabbit polyclonal antibody to ADSSL1
アプリケーション: WB IF/ICC
反応性: Human, Mouse
分子量: 50kD(Calculated).
ユニプロット: Q8N142

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
クローナリティ:
Polyclonal
特異性:
ADSSL1 Antibody detects endogenous levels of ADSSL1.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

Adenylosuccinate synthase like 1; Adenylosuccinate synthetase; Adenylosuccinate synthetase isozyme 1; AdSS 1; ADSS1; ADSSL1; AMPSase 1; basic isozyme; IMP aspartate ligase 1; IMP--aspartate ligase 1; M-type adenylosuccinate synthetase; muscle isozyme; PURA1_HUMAN;

免疫原

免疫原:

A synthesized peptide derived from human ADSSL1.

Uniprot:
遺伝子(ID):
発現特異性:
Q8N142 PURA1_HUMAN:

Predominantly expressed in skeletal muscle and heart, as well as in several hematopoietic cell lines and solid tumors.

タンパク質配列:
MSGTRASNDRPPGAGGVKRGRLQQEAAATGSRVTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLKDWEKRLIISDRAHLVFDFHQAVDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSDFDEFSSRFKNLAHQHQSMFPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQLF

研究背景

機能:

Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

細胞の位置付け:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Predominantly expressed in skeletal muscle and heart, as well as in several hematopoietic cell lines and solid tumors.

サブユニット構造:

Homodimer.

タンパク質ファミリー:

Belongs to the adenylosuccinate synthetase family.

研究領域

· Metabolism > Nucleotide metabolism > Purine metabolism.

· Metabolism > Amino acid metabolism > Alanine, aspartate and glutamate metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

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