CD34 Antibody - #DF16119
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
CD34; CD34 antigen; CD34 molecule; CD34_HUMAN; Cluster designation 34; Hematopoietic progenitor cell antigen CD34; HPCA1; Mucosialin; OTTHUMP00000034733; OTTHUMP00000034734;
免疫原
A synthesized peptide derived from human CD34.
Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.
- P28906 CD34_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLVRRGARAGPRMPRGWTALCLLSLLPSGFMSLDNNGTATPELPTQGTFSNVSTNVSYQETTTPSTLGSTSLHPVSQHGNEATTNITETTVKFTSTSVITSVYGNTNSSVQSQTSVISTVFTTPANVSTPETTLKPSLSPGNVSDLSTTSTSLATSPTKPYTSSSPILSDIKAEIKCSGIREVKLTQGICLEQNKTSSCAEFKKDRGEGLARVLCGEEQADADAGAQVCSLLLAQSEVRPQCLLLVLANRTEISSKLQLMKKHQSDLKKLGILDFTEQDVASHQSYSQKTLIALVTSGALLAVLGITGYFLMNRRSWSPTGERLGEDPYYTENGGGQGYSSGPGTSPEAQGKASVNRGAQENGTGQATSRNGHSARQHVVADTEL
PTMs - P28906 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S198 | Phosphorylation | Uniprot | |
| K268 | Acetylation | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| Y286 | Phosphorylation | Uniprot | |
| Y329 | Phosphorylation | Uniprot | |
| Y330 | Phosphorylation | Uniprot | |
| T331 | Phosphorylation | Uniprot | |
| Y339 | Phosphorylation | Uniprot | |
| S341 | Phosphorylation | Uniprot | |
| S346 | Phosphorylation | P31751 (AKT2) | Uniprot |
| S354 | Phosphorylation | Uniprot |
研究背景
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
Highly glycosylated.
Phosphorylated on serine residues by PKC.
Membrane>Single-pass type I membrane protein.
Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.
Belongs to the CD34 family.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
· Organismal Systems > Immune system > Hematopoietic cell lineage. (View pathway)
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