AFfirm™ Cytokeratin 4 Mouse Monoclonal Antibody - #BF8030
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
CK 4; CK-4; CK4; CYK4; Cytokeratin 4; Cytokeratin-4; Cytokeratin4; FLJ31692; K2C4_HUMAN; K4; Keratin 4; Keratin; Keratin type II cytoskeletal 4; Keratin-4; Keratin4; KRT 4; Krt4; type II cytoskeletal 4; Type-II keratin Kb4;
免疫原
A synthesized peptide derived from Human Cytokeratin 4.
Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer.
- P19013 K2C4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MIARQQCVRGGPRGFSCGSAIVGGGKRGAFSSVSMSGGAGRCSSGGFGSRSLYNLRGNKSISMSVAGSRQGACFGGAGGFGTGGFGGGFGGSFSGKGGPGFPVCPAGGIQEVTINQSLLTPLHVEIDPEIQKVRTEEREQIKLLNNKFASFIDKVQFLEQQNKVLETKWNLLQQQTTTTSSKNLEPLFETYLSVLRKQLDTLGNDKGRLQSELKTMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYLNKVELEAKVDSLNDEINFLKVLYDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVRAQYEEIAQRSKAEAEALYQTKVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLRAEIENIKKQCQTLQVSVADAEQRGENALKDAHSKRVELEAALQQAKEELARMLREYQELMSVKLALDIEIATYRKLLEGEEYRMSGECQSAVSISVVSGSTSTGGISGGLGSGSGFGLSSGFGSGSGSGFGFGGSVSGSSSSKIISTTTLNKRR
PTMs - P19013 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S16 | Phosphorylation | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| K26 | Acetylation | Uniprot | |
| S31 | Phosphorylation | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| S34 | Phosphorylation | Uniprot | |
| S36 | Phosphorylation | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| Y53 | Phosphorylation | Uniprot | |
| S60 | Phosphorylation | Uniprot | |
| S64 | Phosphorylation | Uniprot | |
| S68 | Phosphorylation | Uniprot | |
| K161 | Ubiquitination | Uniprot | |
| S164 | Phosphorylation | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| Y241 | Phosphorylation | Uniprot | |
| K259 | Acetylation | Uniprot | |
| Y266 | Phosphorylation | Uniprot | |
| K269 | Acetylation | Uniprot | |
| Y329 | Phosphorylation | Uniprot | |
| Y344 | Phosphorylation | Uniprot | |
| T346 | Phosphorylation | Uniprot | |
| S413 | Phosphorylation | Uniprot | |
| Y436 | Phosphorylation | Uniprot | |
| S441 | Phosphorylation | Uniprot | |
| Y462 | Phosphorylation | Uniprot |
研究背景
Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer.
Heterotetramer of two type I and two type II keratins. Keratin-4 is generally associated with keratin-13.
Belongs to the intermediate filament family.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.