PSD93 Antibody - #AF2689
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
Channel associated protein of synapse 110; Channel associated protein of synapses 110kD; Channel-associated protein of synapse-110; Chapsyn 110; Chapsyn-110; Chapsyn110; Discs, large homolog 2 (Drosophila); Disks large homolog 2; DKFZp781D1854; DKFZp781E0954; Dlg 2; dlg2; DLG2_HUMAN; Dlgh 2; Dlgh2; FLJ37266; Gm1197; MGC131811; Postsynaptic density protein PSD 93; Postsynaptic density protein PSD-93; Postsynaptic density protein PSD93; PSD 93; PSD93;
免疫原
A synthesized peptide derived from human PSD93, corresponding to a region within the N-terminal amino acids.
- Q15700 DLG2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
PTMs - Q15700 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S28 | Phosphorylation | Uniprot | |
| S175 | Phosphorylation | Uniprot | |
| Y180 | Phosphorylation | Uniprot | |
| T225 | Phosphorylation | Uniprot | |
| T257 | Phosphorylation | Uniprot | |
| T317 | Phosphorylation | Uniprot | |
| S318 | Phosphorylation | Uniprot | |
| S323 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| Y327 | Phosphorylation | Uniprot | |
| Y340 | Phosphorylation | Uniprot | |
| Y348 | Phosphorylation | Uniprot | |
| S365 | Phosphorylation | Uniprot | |
| S414 | Phosphorylation | Uniprot | |
| K511 | Ubiquitination | Uniprot | |
| S523 | Phosphorylation | Uniprot | |
| S530 | Phosphorylation | Uniprot | |
| S553 | Phosphorylation | Uniprot | |
| S598 | Phosphorylation | Uniprot | |
| S627 | Phosphorylation | Uniprot | |
| S635 | Phosphorylation | Uniprot | |
| K690 | Ubiquitination | Uniprot | |
| Y719 | Phosphorylation | Uniprot | |
| Y726 | Phosphorylation | Uniprot |
研究背景
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).
Palmitoylation of isoform 1 is not required for targeting to postsynaptic density.
Cell membrane>Lipid-anchor. Cell junction>Synapse>Postsynaptic density. Cell junction>Synapse. Membrane. Cell projection>Axon. Perikaryon.
Note: Concentrated in soma and postsynaptic density of a subset of neurons.
Interacts through its PDZ domains with NETO1 (By similarity). Interacts with NOS1/nNOS through second PDZ domain (By similarity). Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains. Interacts with KCNJ4 (By similarity), Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Interacts with FASLG. Interacts with KCNJ4 (By similarity). Interacts with ADAM22 (By similarity).
An N-terminally truncated L27 domain is predicted in isoform 2 at positions 1 through 27.
Belongs to the MAGUK family.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)
· Environmental Information Processing > Signal transduction > Hippo signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
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