AFfirm™ ACTR3 Mouse Monoclonal Antibody - #BF8074
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
Actin like protein 3; Actin related protein 3; ACTR3; ARP3 actin related protein 3 homolog (yeast);
免疫原
- P61158 ARP3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVMKGVDDLDFFIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGVMS
PTMs - P61158 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| C8 | S-Nitrosylation | Uniprot | |
| C12 | S-Nitrosylation | Uniprot | |
| Y16 | Phosphorylation | Uniprot | |
| K18 | Ubiquitination | Uniprot | |
| K38 | Ubiquitination | Uniprot | |
| K42 | Ubiquitination | Uniprot | |
| K53 | Acetylation | Uniprot | |
| K53 | Ubiquitination | Uniprot | |
| K69 | Ubiquitination | Uniprot | |
| K75 | Ubiquitination | Uniprot | |
| K99 | Ubiquitination | Uniprot | |
| Y100 | Phosphorylation | Uniprot | |
| Y109 | Phosphorylation | Uniprot | |
| T113 | Phosphorylation | Uniprot | |
| T119 | Phosphorylation | Uniprot | |
| S133 | Phosphorylation | Uniprot | |
| Y140 | Phosphorylation | Uniprot | |
| S152 | Phosphorylation | Uniprot | |
| Y184 | Phosphorylation | Uniprot | |
| K191 | Ubiquitination | Uniprot | |
| T201 | Phosphorylation | Uniprot | |
| Y202 | Phosphorylation | Uniprot | |
| K225 | Ubiquitination | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| Y231 | Phosphorylation | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| Y233 | Phosphorylation | Uniprot | |
| K240 | Acetylation | Uniprot | |
| K240 | Ubiquitination | Uniprot | |
| K244 | Acetylation | Uniprot | |
| K244 | Ubiquitination | Uniprot | |
| K251 | Acetylation | Uniprot | |
| K251 | Ubiquitination | Uniprot | |
| K254 | Acetylation | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| K264 | Sumoylation | Uniprot | |
| K264 | Ubiquitination | Uniprot | |
| K265 | Ubiquitination | Uniprot | |
| S268 | Phosphorylation | Uniprot | |
| K317 | Ubiquitination | Uniprot | |
| S322 | Phosphorylation | Uniprot | |
| S325 | Phosphorylation | Uniprot | |
| T326 | Phosphorylation | Uniprot | |
| K348 | Ubiquitination | Uniprot | |
| S350 | Phosphorylation | Uniprot | |
| S354 | Phosphorylation | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| K361 | Ubiquitination | Uniprot | |
| K398 | Ubiquitination | Uniprot | |
| Y400 | Phosphorylation | Uniprot | |
| S418 | Phosphorylation | Uniprot |
研究背景
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis.
Cytoplasm>Cytoskeleton. Cell projection. Nucleus.
Note: In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (PubMed:19109554).
Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1. Interacts weakly with MEFV.
Belongs to the actin family. ARP3 subfamily.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)
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