AFfirm™ PGRMC1 Mouse Monoclonal Antibody - #BF8084
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
HPR6.6; Membrane associated progesterone receptor component 1; Membrane-associated progesterone receptor component 1; mPR; PGRC1_HUMAN; PGRMC; Pgrmc1; Progesterone binding protein; Progesterone receptor membrane component 1;
免疫原
A synthesized peptide derived from human PGRMC1, corresponding to a region within C-terminal amino acids.
- O00264 PGRC1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPAASGDSDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQFTFKYHHVGKLLKEGEEPTVYSDEEEPKDESARKND
PTMs - O00264 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R47 | Methylation | Uniprot | |
| S54 | Phosphorylation | Uniprot | |
| S57 | Phosphorylation | Uniprot | |
| T74 | Phosphorylation | Uniprot | |
| R79 | Methylation | Uniprot | |
| K96 | Acetylation | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| T101 | Phosphorylation | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| Y107 | Phosphorylation | Uniprot | |
| Y113 | Phosphorylation | Uniprot | |
| R119 | Methylation | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| K136 | Ubiquitination | Uniprot | |
| Y139 | Phosphorylation | Uniprot | |
| S143 | Phosphorylation | Uniprot | |
| T146 | Phosphorylation | Uniprot | |
| T152 | Phosphorylation | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| K169 | Ubiquitination | Uniprot | |
| K172 | Ubiquitination | Uniprot | |
| T178 | Phosphorylation | Uniprot | |
| Y180 | Phosphorylation | Uniprot | |
| S181 | Phosphorylation | Uniprot | |
| K187 | Ubiquitination | Uniprot | |
| S190 | Phosphorylation | Uniprot |
研究背景
Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs).
Microsome membrane>Single-pass membrane protein. Smooth endoplasmic reticulum membrane>Single-pass membrane protein.
Widely expressed, with highest expression in liver and kidney.
Homodimer. Forms stable homodimer through hydrophobic heme-heme stacking interactions.
The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.
Belongs to the cytochrome b5 family. MAPR subfamily.
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