AFfirm™ Synapsin I Mouse Monoclonal Antibody - #BF8185
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
Brain protein 4.1; SYN 1; SYN 1a; SYN 1b; SYN I; SYN1; SYN1_HUMAN; SYN1a; SYN1b; Synapsin 1; Synapsin I; Synapsin-1; Synapsin1; SynapsinI; SYNI;
免疫原
- P17600 SYN1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNYLRRRLSDSNFMANLPNGYMTDLQRPQPPPPPPGAHSPGATPGPGTATAERSSGVAPAASPAAPSPGSSGGGGFFSSLSNAVKQTTAAAAATFSEQVGGGSGGAGRGGAASRVLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFSMARNGDYRSLVIGLQYAGIPSVNSLHSVYNFCDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQDIASVVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVEALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNKMAQALPRQRQRDASPGRGSHGQTPSPGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPATAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDEVKAETIRSLRKSFASLFSD
PTMs - P17600 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S9 | Phosphorylation | Q14012 (CAMK1) , Q13131 (PRKAA1) | Uniprot |
| S11 | Phosphorylation | Uniprot | |
| S39 | Phosphorylation | Uniprot | |
| S62 | Phosphorylation | P27361 (MAPK3) | Uniprot |
| S67 | Phosphorylation | P27361 (MAPK3) | Uniprot |
| S293 | Phosphorylation | Uniprot | |
| Y301 | Phosphorylation | Uniprot | |
| S332 | Phosphorylation | Uniprot | |
| S427 | Phosphorylation | Uniprot | |
| S432 | Phosphorylation | Uniprot | |
| T436 | Phosphorylation | Uniprot | |
| S438 | Phosphorylation | Q8TAS1 (UHMK1) | Uniprot |
| T448 | Phosphorylation | Uniprot | |
| S449 | Phosphorylation | Uniprot | |
| S551 | Phosphorylation | P27361 (MAPK3) , Q00535 (CDK5) | Uniprot |
| S553 | Phosphorylation | Q00535 (CDK5) | Uniprot |
| T567 | Phosphorylation | Uniprot | |
| S568 | Phosphorylation | Uniprot | |
| S605 | Phosphorylation | Uniprot | |
| T613 | Phosphorylation | Uniprot | |
| S698 | Phosphorylation | Uniprot |
研究背景
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal.
Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.
Cell junction>Synapse. Golgi apparatus.
Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1. Isoform Ib interacts with PRNP (By similarity).
The A region binds phospholipids with a preference for negatively charged species.
Belongs to the synapsin family.
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