AFfirm™ ZAK Mouse Monoclonal Antibody - #BF8261
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
AZK; Cervical cancer suppressor gene 4 protein; HCCS 4; HCCS-4; HCCS4; Human cervical cancer suppressor gene 4 protein; Leucine zipper and sterile alpha motif containing kinase; Leucine zipper- and sterile alpha motif-containing kinase; Mitogen activated protein kinase kinase kinase MLT; Mitogen-activated protein kinase kinase kinase MLT; Mixed lineage kinase 7; Mixed lineage kinase related kinase; Mixed lineage kinase related kinase MRK beta; Mixed lineage kinase with a leucine zipper and a sterile alpha motif; Mixed lineage kinase-related kinase; MLK 7; MLK like mitogen activated protein triple kinase; MLK related kinase; MLK-like mitogen-activated protein triple kinase; MLK-related kinase; MLK7; Mlklak; MLT; MLTK_HUMAN; MRK; Sterile alpha motif and leucine zipper containing kinase AZK; Sterile alpha motif- and leucine zipper-containing kinase AZK; Zak;
免疫原
Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.
- Q9NYL2 M3K20_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPLIKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNTNLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQDEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSPFFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFSSGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQSALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRPSPAKTNKERARGDHRGWRNF
PTMs - Q9NYL2 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | Uniprot | |
| S3 | Phosphorylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| K34 | Ubiquitination | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| Y78 | Phosphorylation | Uniprot | |
| Y84 | Phosphorylation | Uniprot | |
| Y93 | Phosphorylation | Uniprot | |
| K116 | Acetylation | Uniprot | |
| Y120 | Phosphorylation | Uniprot | |
| K128 | Ubiquitination | Uniprot | |
| S136 | Phosphorylation | Uniprot | |
| S155 | Phosphorylation | Uniprot | |
| T161 | Phosphorylation | Q9NYL2 (MAP3K20) | Uniprot |
| T162 | Phosphorylation | Q9NYL2 (MAP3K20) | Uniprot |
| S165 | Phosphorylation | Q9NYL2 (MAP3K20) | Uniprot |
| K248 | Ubiquitination | Uniprot | |
| T267 | Phosphorylation | Uniprot | |
| S268 | Phosphorylation | Uniprot | |
| K272 | Ubiquitination | Uniprot | |
| S275 | Phosphorylation | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| K304 | Ubiquitination | Uniprot | |
| K309 | Ubiquitination | Uniprot | |
| K316 | Ubiquitination | Uniprot | |
| K354 | Acetylation | Uniprot | |
| S362 | Phosphorylation | Uniprot | |
| S366 | Phosphorylation | Uniprot | |
| K369 | Acetylation | Uniprot | |
| K376 | Acetylation | Uniprot | |
| K401 | Ubiquitination | Uniprot | |
| K538 | Acetylation | Uniprot | |
| K544 | Acetylation | Uniprot | |
| S557 | Phosphorylation | Uniprot | |
| S563 | Phosphorylation | Uniprot | |
| S565 | Phosphorylation | Uniprot | |
| S567 | Phosphorylation | Uniprot | |
| S568 | Phosphorylation | Uniprot | |
| T576 | Phosphorylation | Uniprot | |
| S584 | Phosphorylation | Uniprot | |
| T586 | Phosphorylation | Uniprot | |
| S591 | Phosphorylation | Uniprot | |
| S593 | Phosphorylation | Uniprot | |
| S599 | Phosphorylation | Uniprot | |
| S603 | Phosphorylation | Uniprot | |
| S610 | Phosphorylation | Uniprot | |
| T628 | Phosphorylation | Uniprot | |
| S633 | Phosphorylation | Uniprot | |
| S635 | Phosphorylation | Uniprot | |
| S636 | Phosphorylation | Uniprot | |
| S637 | Phosphorylation | Uniprot | |
| T639 | Phosphorylation | Uniprot | |
| S648 | Phosphorylation | Uniprot | |
| S649 | Phosphorylation | Uniprot | |
| S654 | Phosphorylation | Uniprot | |
| S660 | Phosphorylation | Uniprot | |
| S661 | Phosphorylation | Uniprot | |
| T666 | Phosphorylation | Uniprot | |
| S667 | Phosphorylation | Uniprot | |
| S668 | Phosphorylation | Uniprot | |
| R670 | Methylation | Uniprot | |
| Y673 | Phosphorylation | Uniprot | |
| S674 | Phosphorylation | Uniprot | |
| R683 | Methylation | Uniprot | |
| S685 | Phosphorylation | Uniprot | |
| S687 | Phosphorylation | Uniprot | |
| S690 | Phosphorylation | Uniprot | |
| S691 | Phosphorylation | Uniprot | |
| R693 | Methylation | Uniprot | |
| T704 | Phosphorylation | Uniprot | |
| R707 | Methylation | Uniprot | |
| R709 | Methylation | Uniprot | |
| K713 | Methylation | Uniprot | |
| S718 | Phosphorylation | Uniprot | |
| S720 | Phosphorylation | Uniprot | |
| S727 | Phosphorylation | Uniprot | |
| S733 | Phosphorylation | Uniprot | |
| S757 | Phosphorylation | Uniprot | |
| S761 | Phosphorylation | Uniprot | |
| S764 | Phosphorylation | Uniprot | |
| T769 | Phosphorylation | Uniprot | |
| K770 | Ubiquitination | Uniprot | |
| S781 | Phosphorylation | Uniprot |
PTMs - Q9NYL2 酵素として
研究背景
Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Involved in limb development.
Phosphorylates histone H3 at 'Ser-28'. May have role in neoplastic cell transformation and cancer development. Causes cell shrinkage and disruption of actin stress fibers.
Cytoplasm. Nucleus.
Note: Translocates to the nucleus upon ultraviolet B irradiation.
Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.
Homodimer. Interacts with PKN1 and ZNF33A. Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, MAP3K20 and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and MAP3K20.
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
研究領域
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
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