AFfirm™ NRF1 Mouse Monoclonal Antibody - #BF8271
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
alpha pal; alpha palindromic binding protein; Alpha palindromic-binding protein; Alpha-pal; locus control region factor 1; NFE2 related factor 1; NRF-1; Nrf1; NRF1_HUMAN; Nuclear respiratory factor 1;
免疫原
- Q16656 NRF1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKKRKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQEVNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCYKQHGREDLLYAFEDQQTQTQATATHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNWATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAAVGALTGVQDANGLVQIPVSMYQTVVTSLAQGNGPVQVAMAPVTTRISDSAVTMDGQAVEVVTLEQ
PTMs - Q16656 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S39 | Phosphorylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| S46 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| S52 | Phosphorylation | Uniprot | |
| T87 | Phosphorylation | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| S99 | Phosphorylation | Uniprot | |
| T109 | Phosphorylation | Uniprot | |
| T118 | Phosphorylation | Uniprot | |
| Y122 | Phosphorylation | Uniprot | |
| T123 | Phosphorylation | Uniprot | |
| S136 | Phosphorylation | Uniprot | |
| S138 | Phosphorylation | Uniprot | |
| K139 | Ubiquitination | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| K221 | Acetylation | Uniprot | |
| K226 | Acetylation | Uniprot | |
| T259 | Phosphorylation | Uniprot | |
| K267 | Ubiquitination | Uniprot |
研究背景
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Phosphorylation enhances DNA binding.
Nucleus.
Ubiquitously expressed with strongest expression in skeletal muscle.
Homodimer. Binds DNA as a dimer. Interacts with PPRC1.
Belongs to the NRF1/Ewg family.
研究領域
· Environmental Information Processing > Signal transduction > Apelin signaling pathway. (View pathway)
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
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