AFfirm™ ADAM9 Mouse Monoclonal Antibody - #BF8314
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
A disintegrin and metalloproteinase domain 9; ADAM 9; ADAM metallopeptidase domain 9; Cellular disintegrin related protein; Cone rod dystrophy 9; CORD9; Disintegrin and metalloproteinase domain 9; Disintegrin and metalloproteinase domain containing protein 9; KIAA0021; MCMP; MDC 9; MDC9; Meltrin gamma; Metalloprotease disintegrin cysteine rich protein 9; Mltng; Myeloma cell metalloproteinase;
免疫原
Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart.
- Q13443 ADAM9_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAAKQPQQFPSRPPPPQPKVSSQGNLIPARPAPAPPLYSSLT
PTMs - Q13443 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K85 | Ubiquitination | Uniprot | |
| K184 | Acetylation | Uniprot | |
| K188 | Acetylation | Uniprot | |
| Y213 | Phosphorylation | Uniprot | |
| Y250 | Phosphorylation | Uniprot | |
| S364 | Phosphorylation | Uniprot | |
| S377 | Phosphorylation | Uniprot | |
| S379 | Phosphorylation | Uniprot | |
| K392 | Ubiquitination | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| K450 | Ubiquitination | Uniprot | |
| S451 | Phosphorylation | Uniprot | |
| Y457 | Phosphorylation | Uniprot | |
| K533 | Acetylation | Uniprot | |
| K546 | Ubiquitination | Uniprot | |
| K561 | Ubiquitination | Uniprot | |
| T735 | Phosphorylation | Uniprot | |
| Y736 | Phosphorylation | Uniprot | |
| S738 | Phosphorylation | Uniprot | |
| K741 | Ubiquitination | Uniprot | |
| S747 | Phosphorylation | Uniprot | |
| S752 | Phosphorylation | Uniprot | |
| S758 | O-Glycosylation | Uniprot | |
| S758 | Phosphorylation | Uniprot | |
| T761 | O-Glycosylation | Uniprot | |
| T761 | Phosphorylation | Uniprot | |
| Y769 | Phosphorylation | Uniprot | |
| R772 | Methylation | Uniprot | |
| T777 | O-Glycosylation | Uniprot | |
| T777 | Phosphorylation | Uniprot | |
| Y778 | Phosphorylation | Uniprot | |
| K781 | Ubiquitination | Uniprot | |
| K796 | Ubiquitination | Uniprot | |
| S798 | Phosphorylation | Uniprot | |
| S799 | Phosphorylation | Uniprot | |
| Y815 | Phosphorylation | Uniprot | |
| S816 | Phosphorylation | Uniprot | |
| S817 | Phosphorylation | Uniprot | |
| T819 | Phosphorylation | Uniprot |
研究背景
Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins.
May act as alpha-secretase for amyloid precursor protein (APP).
Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9.
Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA).
Cell membrane>Single-pass type I membrane protein.
Secreted.
Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart.
Interacts with SH3GL2 and SNX9 through its cytoplasmic tail. Interacts with ITGA6.
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