AFfirm™ c-Myb Mouse Monoclonal Antibody - #BF8298
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
C myb; C myb protein; Cmyb; MYB; Myb proto oncogene; V myb myeloblastosis viral oncogene homolog;
免疫原
A synthesized peptide derived from human c-Myb, corresponding to a region within C-terminal amino acids.
- P10242 MYB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQESSKASQPAVATSFQKNSHLMGFAQAPPTAQLPATGQPTVNNDYSYYHISEAQNVSSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLLMSTENELKGQQVLPTQNHTCSYPGWHSTTIADHTRPHGDSAPVSCLGEHHSTPSLPADPGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSFLNTSSNHENSDLEMPSLTSTPLIGHKLTVTTPFHRDQTVKTQKENTVFRTPAIKRSILESSPRTPTPFKHALAAQEIKYGPLKMLPQTPSHLVEDLQDVIKQESDESGIVAEFQENGPPLLKKIKQEVESPTDKSGNFFCSHHWEGDSLNTQLFTQTSPVADAPNILTSSVLMAPASEDEDNVLKAFTVPKNRSLASPLQPCSSTWEPASCGKMEEQMTSSSQARKYVNAFSARTLVM
PTMs - P10242 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S11 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S12 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| K53 | Ubiquitination | Uniprot | |
| Y69 | Phosphorylation | Uniprot | |
| K84 | Ubiquitination | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| K97 | Ubiquitination | Uniprot | |
| K109 | Ubiquitination | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| S116 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| K120 | Ubiquitination | Uniprot | |
| C130 | S-Nitrosylation | Uniprot | |
| K143 | Sumoylation | Uniprot | |
| K143 | Ubiquitination | Uniprot | |
| K160 | Ubiquitination | Uniprot | |
| K171 | Ubiquitination | Uniprot | |
| K182 | Ubiquitination | Uniprot | |
| K192 | Ubiquitination | Uniprot | |
| K204 | Ubiquitination | Uniprot | |
| K291 | Ubiquitination | Uniprot | |
| K293 | Ubiquitination | Uniprot | |
| K296 | Ubiquitination | Uniprot | |
| T420 | Phosphorylation | Uniprot | |
| T433 | Phosphorylation | Uniprot | |
| K442 | Ubiquitination | Uniprot | |
| K445 | Acetylation | Uniprot | |
| K445 | Ubiquitination | Uniprot | |
| T452 | Phosphorylation | Uniprot | |
| R457 | Methylation | Uniprot | |
| S463 | Phosphorylation | Uniprot | |
| R465 | Methylation | Uniprot | |
| T466 | Phosphorylation | Uniprot | |
| T468 | Phosphorylation | Uniprot | |
| K471 | Acetylation | Uniprot | |
| K471 | Methylation | Uniprot | |
| K471 | Ubiquitination | Uniprot | |
| K480 | Acetylation | Uniprot | |
| K480 | Sumoylation | Uniprot | |
| K480 | Ubiquitination | Uniprot | |
| K485 | Acetylation | Uniprot | |
| K485 | Ubiquitination | Uniprot | |
| K503 | Sumoylation | Uniprot | |
| K527 | Sumoylation | Uniprot | |
| S532 | Phosphorylation | P27361 (MAPK3) | Uniprot |
| T534 | Phosphorylation | Uniprot | |
| K593 | Ubiquitination | Uniprot | |
| S599 | Phosphorylation | Uniprot | |
| K615 | Ubiquitination | Uniprot | |
| T621 | Phosphorylation | Uniprot | |
| S624 | Phosphorylation | Uniprot | |
| K628 | Ubiquitination | Uniprot |
研究背景
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.
Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels.
Nucleus.
Binds MYBBP1A. Interacts with HIPK2, MAF and NLK (By similarity). Binds to HIPK1.
Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.
研究領域
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
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