AFfirm™ RTCD1 Mouse Monoclonal Antibody - #BF8440
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
2310009A18Rik; AI450277; EC 6.5.1.4; MGC102342; MGC94866; RNA 3' terminal phosphate cyclase; RNA 3-prime-terminal phosphate cyclase; RNA cyclase; RNA terminal phosphate cyclase domain 1; RNA terminal phosphate cyclase domain containing protein 1; RNA-3'-phosphate cyclase; RPC; RPC1; RTC domain containing protein 1; RTC1; RTCA; RTCD1;
免疫原
- O00442 RTCA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGPRVEVDGSIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMIRDLCDGQLEGAEIGSTEITFTPEKIKGGIHTADTKTAGSVCLLMQVSMPCVLFAASPSELHLKGGTNAEMAPQIDYTVMVFKPIVEKFGFIFNCDIKTRGYYPKGGGEVIVRMSPVKQLNPINLTERGCVTKIYGRAFVAGVLPFKVAKDMAAAAVRCIRKEIRDLYVNIQPVQEPKDQAFGNGNGIIIIAETSTGCLFAGSSLGKRGVNADKVGIEAAEMLLANLRHGGTVDEYLQDQLIVFMALANGVSRIKTGPVTLHTQTAIHFAEQIAKAKFIVKKSEDEEDAAKDTYIIECQGIGMTNPNL
PTMs - O00442 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S27 | Phosphorylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| K85 | Ubiquitination | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| K163 | Acetylation | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| S173 | Phosphorylation | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| T184 | Phosphorylation | Uniprot | |
| K191 | Ubiquitination | Uniprot | |
| K205 | Methylation | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| K272 | Ubiquitination | Uniprot | |
| T314 | Phosphorylation | Uniprot | |
| C356 | S-Nitrosylation | Uniprot |
研究背景
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Nucleus>Nucleoplasm.
Ubiquitous.
Monomer.
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
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