AFfirm™ p23 Mouse Monoclonal Antibody - #BF8454
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
Co chaperone p23; cPGES; Cytosolic prostaglandin E synthase; Cytosolic prostaglandin E2 synthase; Hsp90 co chaperone; Hsp90 co-chaperone; P23; Progesterone receptor complex; Progesterone receptor complex p23; Prostaglandin E synthase 3 (cytosolic); Prostaglandin E synthase 3; PTGES 3; PTGES3; Sid 3177; TEBP; TEBP_HUMAN; Telomerase binding protein p23; Telomerase-binding protein p23; Unactive progesterone receptor 23 kD;
免疫原
A synthesized peptide derived from human p23.
- Q15185 TEBP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNFDRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE
PTMs - Q15185 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K7 | Acetylation | Uniprot | |
| K7 | Ubiquitination | Uniprot | |
| Y14 | Phosphorylation | Uniprot | |
| K33 | Acetylation | Uniprot | |
| K33 | Methylation | Uniprot | |
| K33 | Sumoylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| K35 | Acetylation | Uniprot | |
| K35 | Sumoylation | Uniprot | |
| K35 | Ubiquitination | Uniprot | |
| S39 | Phosphorylation | Uniprot | |
| C40 | S-Nitrosylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| K48 | Acetylation | Uniprot | |
| K48 | Methylation | Uniprot | |
| K48 | Ubiquitination | Uniprot | |
| C58 | S-Nitrosylation | Uniprot | |
| S64 | Phosphorylation | Uniprot | |
| K65 | Sumoylation | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| K67 | Ubiquitination | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| C75 | S-Nitrosylation | Uniprot | |
| C76 | S-Nitrosylation | Uniprot | |
| K79 | Sumoylation | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| S82 | Phosphorylation | Uniprot | |
| S85 | Phosphorylation | Uniprot | |
| K91 | Acetylation | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| K95 | Sumoylation | Uniprot | |
| K95 | Ubiquitination | Uniprot | |
| S100 | Phosphorylation | Uniprot | |
| S113 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S118 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S124 | Phosphorylation | Uniprot | |
| S148 | Phosphorylation | Uniprot | |
| S151 | Phosphorylation | Uniprot |
研究背景
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.
Cytoplasm.
Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2. Binds to the progesterone receptor. Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex. Interacts (via PXLE motif) with EGLN1/PHD2, recruiting EGLN1/PHD2 to the HSP90 pathway to facilitate HIF alpha proteins hydroxylation. Interacts with HSP90AA1, FLCN, FNIP1 and FNIP2.
The PXLE motif mediates interaction with EGLN1/PHD2.
Belongs to the p23/wos2 family.
研究領域
· Metabolism > Lipid metabolism > Arachidonic acid metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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