CDX2 Antibody - #AF4089

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製品: CDX2 Antibody
カタログ: AF4089
タンパク質の説明: Rabbit polyclonal antibody to CDX2
アプリケーション: WB
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Sheep, Rabbit, Dog, Chicken
分子量: 40kd; 34kD(Calculated).
ユニプロット: Q99626
RRID: AB_2835355

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(100%), Bovine(100%), Sheep(86%), Rabbit(100%), Dog(86%), Chicken(100%)
クローナリティ:
Polyclonal
特異性:
CDX2 Antibody detects endogenous levels of total CDX2.
RRID:
AB_2835355
引用形式: Affinity Biosciences Cat# AF4089, RRID:AB_2835355.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Caudal type homeo box 2; Caudal type homeo box transcription factor 2; Caudal type homeobox 2; Caudal type homeobox protein 2; Caudal type homeobox transcription factor 2; Caudal-type homeobox protein 2; CDX 2; CDX 3; CDX-3; Cdx2; CDX2/AS; CDX2_HUMAN; CDX3; Homeobox protein CDX 2; Homeobox protein CDX-2;

免疫原

免疫原:
Uniprot:

Q99626(CDX2_HUMAN) >>Visit HPA database.

遺伝子(ID):
CDX2(1045)
タンパク質の説明:
Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.
タンパク質配列:
MYVSYLLDKDVSMYPSSVRHSGGLNLAPQNFVSPPQYPDYGGYHVAAAAAAAANLDSAQSPGPSWPAAYGAPLREDWNGYAPGGAAAAANAVAHGLNGGSPAAAMGYSSPADYHPHHHPHHHPHHPAAAPSCASGLLQTLNPGPPGPAATAAAEQLSPGGQRRNLCEWMRKPAQQSLGSQVKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERKINKKKLQQQQQQQPPQPPPPPPQPPQPQPGPLRSVPEPLSPVSSLQASVPGSVPGVLGPTGGVLNPTVTQ

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Bovine
100
Chicken
100
Rabbit
100
Sheep
86
Dog
86
Horse
0
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q99626 基板として

Site PTM Type Enzyme
S4 Phosphorylation
S60 Phosphorylation
S176 Phosphorylation
S226 Phosphorylation
S277 Phosphorylation
S283 Phosphorylation P24941 (CDK2) , Q16539 (MAPK14) , P49841 (GSK3B)
S287 Phosphorylation P24941 (CDK2) , Q16539 (MAPK14)
S291 Phosphorylation P24941 (CDK2) , Q16539 (MAPK14)
S295 Phosphorylation Q16539 (MAPK14)
T310 Phosphorylation
T312 Phosphorylation

研究背景

機能:

Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA.

PTMs:

Phosphorylation of Ser-60 mediates the transactivation capacity.

細胞の位置付け:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
タンパク質ファミリー:

Belongs to the Caudal homeobox family.

研究領域

· Human Diseases > Cancers: Specific types > Gastric cancer.   (View pathway)

参考文献

1). Moderate Treadmill Exercise Modulates Gut Microbiota and Improves Intestinal Barrier in High-Fat-Diet-Induced Obese Mice via the AMPK/CDX2 Signaling Pathway. Diabetes Metabolic Syndrome and Obesity-Target & Therapy, 2022 (PubMed: 35087282) [IF=3.3]

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