製品: DCL-1 Mouse Monoclonal Antibody
カタログ: BF8459
タンパク質の説明: Mouse monoclonal antibody to DCL-1
アプリケーション: IF/ICC
反応性: Human
予測: Pig, Horse, Rabbit, Xenopus
分子量: 26,35kDa; 26kD(Calculated).
ユニプロット: Q8IX05

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製品説明

ソース:
Mouse
アプリケーション:
IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [AFfirm8459]
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

BIMLEC; C type lectin BIMLEC; C type lectin domain family 13 member A; C-type lectin BIMLEC; C-type lectin domain family 13 member A; CD302; CD302 antigen; CD302_HUMAN; CLEC13A; DCL1; KIAA0022; Type I transmembrane C type lectin receptor DCL-1; Type I transmembrane C-type lectin receptor DCL-1;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
Q8IX05 CD302_HUMAN:

Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.

タンパク質配列:
MLRAALPALLLPLLGLAAAAVADCPSSTWIQFQDSCYIFLQEAIKVESIEDVRNQCTDHGADMISIHNEEENAFILDTLKKQWKGPDDILLGMFYDTDDASFKWFDNSNMTFDKWTDQDDDEDLVDTCAFLHIKTGEWKKGNCEVSSVEGTLCKTAIPYKRKYLSDNHILISALVIASTVILTVLGAIIWFLYKKHSDSRFTTVFSTAPQSPYNEDCVLVVGEENEYPVQFD

PTMs - Q8IX05 基板として

Site PTM Type Enzyme
S101 Phosphorylation
K140 Methylation

研究背景

機能:

Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.

PTMs:

May be heterogeneously N-glycosylated in some cell types.

細胞の位置付け:

Membrane>Single-pass type I membrane protein. Cell projection>Filopodium. Cytoplasm>Cell cortex. Cell projection>Microvillus.
Note: Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.

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