AFfirm™ Cytokeratin 16 Mouse Monoclonal Antibody - #BF8505
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
CK 16; CK-16; CK16; Cytokeratin-16; Cytokeratin16; FNEPPK; Focal non epidermolytic palmoplantar keratoderma; K 16; K16; K1C16_HUMAN; K1CP; Keratin 1 type I; Keratin 16; Keratin; Keratin type I cytoskeletal 16; Keratin-16; Keratin16; KRT 16; Krt16; KRT16A; NEPPK; PC1; type I cytoskeletal 16;
免疫原
Expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland ducts.
- P08779 K1C16_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTTCSRQFTSSSSMKGSCGIGGGIGGGSSRISSVLAGGSCRAPSTYGGGLSVSSRFSSGGACGLGGGYGGGFSSSSSFGSGFGGGYGGGLGAGFGGGLGAGFGGGFAGGDGLLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPSEIKDYSPYFKTIEDLRNKIIAATIENAQPILQIDNARLAADDFRTKYEHELALRQTVEADVNGLRRVLDELTLARTDLEMQIEGLKEELAYLRKNHEEEMLALRGQTGGDVNVEMDAAPGVDLSRILNEMRDQYEQMAEKNRRDAETWFLSKTEELNKEVASNSELVQSSRSEVTELRRVLQGLEIELQSQLSMKASLENSLEETKGRYCMQLSQIQGLIGSVEEQLAQLRCEMEQQSQEYQILLDVKTRLEQEIATYRRLLEGEDAHLSSQQASGQSYSSREVFTSSSSSSSRQTRPILKEQSSSSFSQGQSS
PTMs - P08779 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T9 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| S12 | Phosphorylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| K15 | Methylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| S33 | Phosphorylation | Uniprot | |
| S39 | Phosphorylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| T45 | Phosphorylation | Uniprot | |
| Y46 | Phosphorylation | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| S54 | Phosphorylation | Uniprot | |
| S130 | Phosphorylation | Uniprot | |
| Y131 | Phosphorylation | Uniprot | |
| K134 | Acetylation | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| Y153 | Phosphorylation | Uniprot | |
| K162 | Acetylation | Uniprot | |
| S165 | Phosphorylation | Uniprot | |
| Y167 | Phosphorylation | Uniprot | |
| K169 | Acetylation | Uniprot | |
| T204 | Phosphorylation | Uniprot | |
| Y206 | Phosphorylation | Uniprot | |
| T215 | Phosphorylation | Uniprot | |
| T235 | Phosphorylation | Uniprot | |
| Y250 | Phosphorylation | Uniprot | |
| Y293 | Phosphorylation | Uniprot | |
| K311 | Ubiquitination | Uniprot | |
| K317 | Ubiquitination | Uniprot | |
| S321 | Phosphorylation | Uniprot | |
| S329 | Phosphorylation | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| K365 | Ubiquitination | Uniprot | |
| K407 | Ubiquitination | Uniprot | |
| T416 | Phosphorylation | Uniprot | |
| Y417 | Phosphorylation | Uniprot | |
| Y438 | Phosphorylation | Uniprot | |
| S449 | Phosphorylation | Uniprot | |
| S450 | Phosphorylation | Uniprot | |
| S451 | Phosphorylation | Uniprot | |
| S452 | Phosphorylation | Uniprot | |
| K460 | Methylation | Uniprot | |
| S463 | Phosphorylation | Uniprot | |
| S464 | Phosphorylation | Uniprot | |
| S468 | Phosphorylation | Uniprot | |
| S472 | Phosphorylation | Uniprot | |
| S473 | Phosphorylation | Uniprot |
研究背景
Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.
Expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland ducts.
Heterodimer of a type I and a type II keratin. KRT16 associates with KRT6 isomers (KRT6A or KRT6B) (By similarity). Interacts with TCHP. Interacts with TRADD (By similarity).
Belongs to the intermediate filament family.
研究領域
· Organismal Systems > Endocrine system > Estrogen signaling pathway. (View pathway)
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