AFfirm™ Annexin A2 Mouse Monoclonal Antibody - #BF8508
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
Annexin A2; Annexin II; Annexin II, heavy chain; Annexin-2; ANX 2; ANX2; ANX2L4; ANXA2; ANXA2_HUMAN; arylsulfatase B; CAL1H; Calpactin I heavy chain; calpactin I heavy polypeptide (p36); Calpactin I heavy polypeptide; Calpactin-1 heavy chain; chromobindin 8; Chromobindin-8; Epididymis secretory protein Li 270; HEL S 270; LIP2; Lipocortin II; LPC2; LPC2D; p36; P36 protein; PAP-IV; Placental anticoagulant protein IV; Protein I;
免疫原
- P07355 ANXA2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
PTMs - P07355 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| T3 | Phosphorylation | Uniprot | |
| K10 | Acetylation | Uniprot | |
| K10 | Ubiquitination | Uniprot | |
| S12 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S18 | Phosphorylation | Uniprot | |
| T19 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| Y24 | Phosphorylation | P12931 (SRC) | Uniprot |
| S26 | Phosphorylation | P05771 (PRKCB) , P17252 (PRKCA) | Uniprot |
| K28 | Ubiquitination | Uniprot | |
| Y30 | Phosphorylation | Uniprot | |
| T31 | Phosphorylation | Uniprot | |
| T44 | Phosphorylation | Uniprot | |
| K47 | Acetylation | Uniprot | |
| K47 | Ubiquitination | Uniprot | |
| K49 | Acetylation | Uniprot | |
| K49 | Sumoylation | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| T55 | Phosphorylation | Uniprot | |
| T61 | Phosphorylation | Uniprot | |
| Y75 | Phosphorylation | Uniprot | |
| K81 | Ubiquitination | Uniprot | |
| S85 | Phosphorylation | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| S89 | Phosphorylation | Uniprot | |
| S92 | Phosphorylation | Uniprot | |
| T97 | Phosphorylation | Uniprot | |
| K104 | Acetylation | Uniprot | |
| K104 | Ubiquitination | Uniprot | |
| T105 | Phosphorylation | Uniprot | |
| Y109 | Phosphorylation | Uniprot | |
| S112 | Phosphorylation | Uniprot | |
| K115 | Acetylation | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| S117 | Phosphorylation | Uniprot | |
| K119 | Ubiquitination | Uniprot | |
| T123 | Phosphorylation | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| C133 | S-Nitrosylation | Uniprot | |
| S134 | Phosphorylation | Uniprot | |
| T136 | Phosphorylation | Uniprot | |
| Y147 | Phosphorylation | Uniprot | |
| K148 | Acetylation | Uniprot | |
| K148 | Ubiquitination | Uniprot | |
| K152 | Acetylation | Uniprot | |
| K152 | Ubiquitination | Uniprot | |
| K157 | Acetylation | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| S161 | Phosphorylation | Uniprot | |
| T163 | Phosphorylation | Uniprot | |
| S164 | Phosphorylation | Uniprot | |
| K169 | Methylation | Uniprot | |
| K169 | Ubiquitination | Uniprot | |
| K176 | Acetylation | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| S184 | Phosphorylation | Uniprot | |
| Y188 | Phosphorylation | Uniprot | |
| Y199 | Phosphorylation | Uniprot | |
| K204 | Acetylation | Uniprot | |
| K204 | Ubiquitination | Uniprot | |
| K212 | Acetylation | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| S215 | Phosphorylation | Uniprot | |
| T218 | Phosphorylation | Uniprot | |
| S221 | Phosphorylation | Uniprot | |
| K227 | Acetylation | Uniprot | |
| K227 | Methylation | Uniprot | |
| K227 | Ubiquitination | Uniprot | |
| Y232 | Phosphorylation | Uniprot | |
| K233 | Acetylation | Uniprot | |
| K233 | Ubiquitination | Uniprot | |
| S234 | Phosphorylation | Uniprot | |
| Y235 | Phosphorylation | Uniprot | |
| S236 | Phosphorylation | Uniprot | |
| Y238 | Phosphorylation | Uniprot | |
| S243 | Phosphorylation | Uniprot | |
| K246 | Ubiquitination | Uniprot | |
| K249 | Ubiquitination | Uniprot | |
| C262 | S-Nitrosylation | Uniprot | |
| K266 | Sumoylation | Uniprot | |
| K266 | Ubiquitination | Uniprot | |
| Y269 | Phosphorylation | Uniprot | |
| Y275 | Phosphorylation | Uniprot | |
| S277 | Phosphorylation | Uniprot | |
| K279 | Acetylation | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| K281 | Ubiquitination | Uniprot | |
| S296 | Phosphorylation | Uniprot | |
| K302 | Acetylation | Uniprot | |
| K302 | Ubiquitination | Uniprot | |
| S305 | Phosphorylation | Uniprot | |
| K310 | Acetylation | Uniprot | |
| K313 | Acetylation | Uniprot | |
| K313 | Methylation | Uniprot | |
| K313 | Ubiquitination | Uniprot | |
| S314 | Phosphorylation | Uniprot | |
| Y316 | Phosphorylation | Uniprot | |
| Y317 | Phosphorylation | Uniprot | |
| Y318 | Phosphorylation | Uniprot | |
| T323 | Phosphorylation | Uniprot | |
| K324 | Acetylation | Uniprot | |
| K324 | Sumoylation | Uniprot | |
| K324 | Ubiquitination | Uniprot | |
| K329 | Ubiquitination | Uniprot | |
| Y333 | Phosphorylation | Uniprot |
研究背景
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.
Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface.
ISGylated.
Secreted>Extracellular space>Extracellular matrix>Basement membrane. Melanosome.
Note: In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.
Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36 (By similarity). Interacts with ATP1B1 (By similarity). Interacts with DYSF (By similarity). Interacts with COCH. Interacts (via repeat Annexin 1) with PCSK9 (via the C-terminal domain); the interaction inhibits the degradation of LDLR. Interacts with CEACAM1 (via the cytoplasmic domain); this interaction is regulated by phosphorylation of CEACAM1. Interacts with APPL2 and APPL1; targets APPL2 to endosomes and acting in parallel to RAB5A (By similarity).
(Microbial infection) Interacts with human cytomegalovirus (HCMV).
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Belongs to the annexin family.
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