AFfirm™ RPS23 Mouse Monoclonal Antibody - #BF8511
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
40S ribosomal protein S23; FLJ35016; Homolog of yeast ribosomal protein S28; Ribosomal protein S23; RPS 23; RPS23; RS23_HUMAN; S23;
免疫原
- P62266 RS23_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPRS
PTMs - P62266 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K25 | Ubiquitination | Uniprot | |
| K29 | Sumoylation | Uniprot | |
| K29 | Ubiquitination | Uniprot | |
| K37 | Sumoylation | Uniprot | |
| K37 | Ubiquitination | Uniprot | |
| K48 | Sumoylation | Uniprot | |
| K48 | Ubiquitination | Uniprot | |
| K54 | Sumoylation | Uniprot | |
| K54 | Ubiquitination | Uniprot | |
| K60 | Ubiquitination | Uniprot | |
| K76 | Ubiquitination | Uniprot | |
| K80 | Ubiquitination | Uniprot | |
| K108 | Ubiquitination | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| Y134 | Phosphorylation | Uniprot | |
| K135 | Acetylation | Uniprot |
研究背景
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy.
Hydroxylation at Pro-62 affects translation termination efficiency.
Cytoplasm>Cytosol. Cytoplasm. Rough endoplasmic reticulum.
Note: Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Component of the 40S small ribosomal subunit.
Belongs to the universal ribosomal protein uS12 family.
研究領域
· Genetic Information Processing > Translation > Ribosome.
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