AFfirm™ ASAP1 Mouse Monoclonal Antibody - #BF8533
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ/展開
130 kDa phosphatidylinositol 4 5 biphosphate dependent ARF1 GTPase activating protein; 130 kDa phosphatidylinositol 4; 5-biphosphate-dependent ARF1 GTPase-activating protein; ADP ribosylation factor directed GTPase activating protein 1; ADP-ribosylation factor-directed GTPase-activating protein 1; AMAP 1; AMAP1; ANK repeat and PH domain-containing protein 1; ARF GTPase activating protein 1; ARF GTPase-activating protein 1; Arf-GAP with SH3 domain; ASAP 1; ASAP1; ASAP1_HUMAN; Centaurin beta 4; CentB4; DDEF 1; DDEF1 protein; DEF-1; Development and differentiation enhancing factor 1; Development and differentiation-enhancing factor 1; Differentiation-enhancing factor 1; KIAA1249; PAG 2; PAG2; PAP; PIP2 dependent ARF1 GAP; PIP2-dependent ARF1 GAP; ZG 14P; ZG14P;
免疫原
- Q9ULH1 ASAP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
PTMs - Q9ULH1 基板として
Site | PTM Type | Enzyme | Source |
---|---|---|---|
S10 | Phosphorylation | Uniprot | |
T34 | Phosphorylation | Uniprot | |
K101 | Ubiquitination | Uniprot | |
S129 | Phosphorylation | Uniprot | |
K182 | Acetylation | Uniprot | |
K184 | Acetylation | Uniprot | |
K209 | Ubiquitination | Uniprot | |
K232 | Ubiquitination | Uniprot | |
K256 | Ubiquitination | Uniprot | |
K276 | Ubiquitination | Uniprot | |
K284 | Ubiquitination | Uniprot | |
S305 | Phosphorylation | Uniprot | |
Y312 | Phosphorylation | Uniprot | |
T372 | Phosphorylation | Uniprot | |
S433 | Phosphorylation | Uniprot | |
S493 | Phosphorylation | Uniprot | |
S514 | Phosphorylation | Uniprot | |
S525 | Phosphorylation | Uniprot | |
K555 | Acetylation | Uniprot | |
K563 | Acetylation | Uniprot | |
S717 | Phosphorylation | Uniprot | |
S726 | Phosphorylation | Uniprot | |
S733 | Phosphorylation | Uniprot | |
S738 | Phosphorylation | Uniprot | |
S744 | Phosphorylation | Uniprot | |
S746 | Phosphorylation | Uniprot | |
S757 | Phosphorylation | Uniprot | |
T758 | Phosphorylation | Uniprot | |
Y767 | Phosphorylation | Q14289 (PTK2B) | Uniprot |
K800 | Ubiquitination | Uniprot | |
S816 | Phosphorylation | Uniprot | |
K824 | Ubiquitination | Uniprot | |
T837 | Phosphorylation | Uniprot | |
S839 | Phosphorylation | Uniprot | |
S843 | Phosphorylation | Uniprot | |
S865 | Phosphorylation | Uniprot | |
S877 | Phosphorylation | Uniprot | |
S881 | Phosphorylation | Uniprot | |
K905 | Acetylation | Uniprot | |
S910 | Phosphorylation | Uniprot | |
T915 | Phosphorylation | Uniprot | |
S924 | Phosphorylation | Uniprot | |
S925 | Phosphorylation | Uniprot | |
S1008 | Phosphorylation | Uniprot | |
S1027 | Phosphorylation | Uniprot | |
S1032 | Phosphorylation | Uniprot | |
S1041 | Phosphorylation | Uniprot | |
S1044 | Phosphorylation | Uniprot | |
T1048 | Phosphorylation | Uniprot | |
T1054 | Phosphorylation | Uniprot | |
T1097 | Phosphorylation | Uniprot | |
S1122 | Phosphorylation | Uniprot | |
S1128 | Phosphorylation | Uniprot |
研究背景
Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.
Phosphorylated on tyrosine residues by SRC.
Cytoplasm. Membrane.
Note: Predominantly cytoplasmic. Partially membrane-associated.
Homodimer. Interacts with SRC and CRK. Interacts with RAB11FIP3. Interacts with PTK2B/PYK2 (By similarity). Interacts with CTTN. Interacts (via SH3 domain) with APC.
The PH domain most probably contributes to the phosphoinositide-dependent regulation of ADP ribosylation factors.
研究領域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis. (View pathway)
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.