AFfirm™ DZIP3 Mouse Monoclonal Antibody - #BF8536
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
DAZ-interacting protein 3; E3 ubiquitin-protein ligase DZIP3; hRUL138; KIAA0675; RNA-binding ubiquitin ligase of 138 kDa;
免疫原
Widely expressed at low level. Highly expressed in skeletal muscle, kidney and heart. Expressed at low level in placenta, lung, brain, liver and pancreas.
- Q86Y13 DZIP3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDSLPDEFFVRHPAVEDQRKEETENKLEKSSGQLNKQENDIPTDLVPVNLLLEVKKLLNAINTLPKGVVPHIKKFLQEDFSFQTMQREVAANSQNGEEIVPALTLRFLITQLEAALRNIQAGNYTAHQINIGYYLTLLFLYGVALTERGKKEDYTEAENKFLVMKMMIQENEICENFMSLVYFGRGLLRCAQKRYNGGLLEFHKSLQEIGDKNDHWFDIDPTEDEDLPTTFKDLLNNFIKTTESNIMKQTICSYLDCERSCEADILKNTSYKGFFQLMCSKSCCVYFHKICWKKFKNLKYPGENDQSFSGKKCLKEGCTGDMVRMLQCDVPGIVKILFEVVRKDEYITIENLGASYRKLISLKITDTDIRPKISLKFNTKDEMPIFKLDYNYFYHLLHIIIISGTDIVRQIFDEAMPPPLLKKELLIHKNVLESYYNHLWTNHPLGGSWHLLYPPNKELPQSKQFDLCLLLALIKHLNVFPAPKKGWNMEPPSSDISKSADILRLCKYRDILLSEILMNGLTESQFNSIWKKVSDILLRLGMMQEDIDKVKENPIENISLDYHQLSVYLGIPVPEIIQRMLSCYQQGIALQSITGSQRIEIEELQNEEEELSPPLMEYNINVKSHPEIQFAEINKDGTSIPSESSTESLKDLQEVKSKQRKKKKTKNKKNKDSKEDQVPYVVEKEEQLRKEQANPHSVSRLIKDDASDVQEDSAMEDKFYSLDELHILDMIEQGSAGKVTTDYGETEKERLARQRQLYKLHYQCEDFKRQLRTVTFRWQENQMQIKKKDKIIASLNQQVAFGINKVSKLQRQIHAKDNEIKNLKEQLSMKRSQWEMEKHNLESTMKTYVSKLNAETSRALTAEVYFLQCRRDFGLLHLEQTEKECLNQLARVTHMAASNLESLQLKAAVDSWNAIVADVRNKIAFLRTQYNEQINKVKQGFALSTLPPVQLPPPPPSPEILMQQFLGRPLVKESFFRPILTVPQMPAVCPGVVSATGQPRAPLMTGIAWALPAPVGDAVPPSAGLRSDPSIMNWERITDRLKTAFPQQTRKELTDFLRKLKDAYGKSLSELTFDEIVCKISQFIDPKKSQSQGKSVSNVNCVSPSHSPSQPDAAQPPKPAWRPLTSQGPATWEGASNPDEEEEEEEPCVICHENLSPENLSVLPCAHKFHAQCIRPWLMQQGTCPTCRLHVLLPEEFPGHPSRQLPKI
PTMs - Q86Y13 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S3 | Phosphorylation | Uniprot | |
| K29 | Ubiquitination | Uniprot | |
| K36 | Ubiquitination | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| T229 | Phosphorylation | Uniprot | |
| T242 | Phosphorylation | Uniprot | |
| K248 | Ubiquitination | Uniprot | |
| K299 | Ubiquitination | Uniprot | |
| K311 | Ubiquitination | Uniprot | |
| K315 | Ubiquitination | Uniprot | |
| T319 | Phosphorylation | Uniprot | |
| K363 | Ubiquitination | Uniprot | |
| K372 | Ubiquitination | Uniprot | |
| K376 | Ubiquitination | Uniprot | |
| K380 | Ubiquitination | Uniprot | |
| Y392 | Phosphorylation | Uniprot | |
| K484 | Ubiquitination | Uniprot | |
| K485 | Ubiquitination | Uniprot | |
| K498 | Ubiquitination | Uniprot | |
| S612 | Phosphorylation | Uniprot | |
| K635 | Ubiquitination | Uniprot | |
| S644 | Phosphorylation | Uniprot | |
| K663 | Acetylation | Uniprot | |
| K664 | Acetylation | Uniprot | |
| K684 | Ubiquitination | Uniprot | |
| K690 | Ubiquitination | Uniprot | |
| K703 | Ubiquitination | Uniprot | |
| S707 | Phosphorylation | Uniprot | |
| K718 | Ubiquitination | Uniprot | |
| K738 | Ubiquitination | Uniprot | |
| K748 | Ubiquitination | Uniprot | |
| K759 | Ubiquitination | Uniprot | |
| K768 | Methylation | Uniprot | |
| K768 | Ubiquitination | Uniprot | |
| K786 | Ubiquitination | Uniprot | |
| K816 | Ubiquitination | Uniprot | |
| K821 | Ubiquitination | Uniprot | |
| K824 | Ubiquitination | Uniprot | |
| K830 | Ubiquitination | Uniprot | |
| K838 | Ubiquitination | Uniprot | |
| K846 | Ubiquitination | Uniprot | |
| K851 | Ubiquitination | Uniprot | |
| K883 | Ubiquitination | Uniprot | |
| K936 | Ubiquitination | Uniprot | |
| K1042 | Ubiquitination | Uniprot | |
| K1051 | Ubiquitination | Uniprot | |
| T1054 | Phosphorylation | Uniprot | |
| K1061 | Ubiquitination | Uniprot | |
| K1066 | Ubiquitination | Uniprot | |
| S1081 | Phosphorylation | Uniprot | |
| K1087 | Ubiquitination | Uniprot | |
| K1088 | Ubiquitination | Uniprot | |
| S1097 | Phosphorylation | Uniprot | |
| S1103 | Phosphorylation | Uniprot | |
| K1118 | Ubiquitination | Uniprot |
研究背景
E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA.
Cytoplasm.
Widely expressed at low level. Highly expressed in skeletal muscle, kidney and heart. Expressed at low level in placenta, lung, brain, liver and pancreas.
Interacts with DAZ proteins.
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