AFfirm™ MBIP1 Mouse Monoclonal Antibody - #BF8548
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
MAP3K12 binding inhibitory protein 1; MAP3K12-binding inhibitory protein 1; MAPK upstream kinase binding inhibitory protein; MAPK upstream kinase-binding inhibitory protein; Mbip; MBIP1_HUMAN; MUK binding inhibitory protein; MUK-binding inhibitory protein; OTTHUMP00000178844;
免疫原
- Q9NS73 MBIP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAATELNRPSSGDRNLERRCRPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKLQSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFSIGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVREFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIPGSGHKPNSMLRDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVSFSGKRRKVQPPQQNYSLAELDEKISALKQALLRKSREAESMATHHLP
PTMs - Q9NS73 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S11 | Phosphorylation | Uniprot | |
| S12 | Phosphorylation | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| K94 | Sumoylation | Uniprot | |
| K94 | Ubiquitination | Uniprot | |
| T107 | Phosphorylation | Uniprot | |
| K118 | Ubiquitination | Uniprot | |
| K129 | Ubiquitination | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K153 | Ubiquitination | Uniprot | |
| S164 | Phosphorylation | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| K301 | Acetylation | Uniprot | |
| K304 | Ubiquitination | Uniprot | |
| K320 | Ubiquitination | Uniprot | |
| K325 | Ubiquitination | Uniprot |
研究背景
Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Nucleus. Cytoplasm.
Note: Shows a cytoplasmic localization when coexpressed with MAP3K12.
Ubiquitous. High expression seen in the heart and lung.
Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, KAT14 and WDR5.
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