AFfirm™ CD300LB Mouse Monoclonal Antibody - #BF8601

製品: CD300LB Mouse Monoclonal Antibody
カタログ: BF8601
タンパク質の説明: Mouse monoclonal antibody to CD300LB
アプリケーション: WB
反応性: Human
分子量: 23 kDa; 23kD(Calculated).
ユニプロット: A8K4G0

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製品説明

ソース:
Mouse
アプリケーション:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [AFfirm8601]
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

CD_antigen=CD300b; CD300 antigen-like family member B; CD300 molecule-like family member b; CD300B; CLM 7; CLM7; CLM7_HUMAN; CMRF35 A2; CMRF35-like molecule 7; CMRF35A2; Immune receptor expressed on myeloid cells 3; IREM 3; IREM3; Leukocyte mono-Ig-like receptor 5; LMIR5; TREM 5; TREM5; Triggering receptor expressed on myeloid cells 5; UNQ2530/PRO6029;

免疫原

免疫原:
Uniprot:

A8K4G0(CLM7_HUMAN) >>Visit HPA database.

遺伝子(ID):
CD300LB(124599)
発現特異性:
A8K4G0 CLM7_HUMAN:

Expressed exclusively in myeloid lineages.

タンパク質配列:
MWLPPALLLLSLSGCFSIQGPESVRAPEQGSLTVQCHYKQGWETYIKWWCRGVRWDTCKILIETRGSEQGEKSDRVSIKDNQKDRTFTVTMEGLRRDDADVYWCGIERRGPDLGTQVKVIVDPEGAASTTASSPTNSNMAVFIGSHKRNHYMLLVFVKVPILLILVTAILWLKGSQRVPEEPGEQPIYMNFSEPLTKDMAT

PTMs - A8K4G0 基板として

Site PTM Type Enzyme
T86 Phosphorylation
T88 Phosphorylation
Y188 Phosphorylation P06241 (FYN)

研究背景

機能:

Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.

PTMs:

Phosphorylation on Tyr-188 by FYN is required for interaction with GRB2.

細胞の位置付け:

Cell membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed exclusively in myeloid lineages.

サブユニット構造:

Interacts with TYROBP, which enhances cell surface expression and activation properties. Interacts with GRB2 in the presence of FYN.

タンパク質ファミリー:

Belongs to the CD300 family.

Restrictive clause

 

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