AFfirm™ CDK5RAP1 Mouse Monoclonal Antibody - #BF8604
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
2310066P17Rik; C20orf34; C42; CDK5 activator binding protein C42; CDK5 activator binding protein C42 like; CDK5 regulatory subunit associated protein 1; CDK5RAP1.3; CDK5RAP1.4; CGI 05; HSPC167; OTTMUSP00000016976; RP23-154J12.6; RP5-1187J4.1;
免疫原
Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
- Q96SZ6 CK5P1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MHPLQCVLQVQRSLGWGPLASVSWLSLRMCRAHSSLSSTMCPSPERQEDGARKDFSSRLAAGPTFQHFLKSASAPQEKLSSEVEDPPPYLMMDELLGRQRKVYLETYGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKALKTRRPRSRVPLRIGILGCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDETYADVMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPIASILEEVKKLSEQVFLPPRPPKVLGLQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNLSRGFTTNYKTKQGGLRFAHLLDQVSRVDPEMRIRFTSPHPKDFPDEVLQLIHERDNICKQIHLPAQSGSSRVLEAMRRGYSREAYVELVHHIRESIPGVSLSSDFIAGFCGETEEDHVQTVSLLREVQYNMGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELITIFREEATKANQTSVGCTQLVLVEGLSKRSATDLCGRNDGNLKVIFPDAEMEDVNNPGLRVRAQPGDYVLVKITSASSQTLRGHVLCRTTLRDSSAYC
PTMs - Q96SZ6 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S37 | Phosphorylation | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| K78 | Ubiquitination | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| K197 | Ubiquitination | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| R298 | Methylation | Uniprot | |
| K346 | Ubiquitination | Uniprot | |
| K378 | Ubiquitination | Uniprot | |
| K396 | Ubiquitination | Uniprot | |
| S406 | Phosphorylation | Uniprot | |
| Y422 | Phosphorylation | Uniprot | |
| Y483 | Phosphorylation | Uniprot | |
| K487 | Ubiquitination | Uniprot | |
| K495 | Ubiquitination | Uniprot | |
| K531 | Ubiquitination | Uniprot | |
| K546 | Acetylation | Uniprot | |
| K546 | Ubiquitination | Uniprot | |
| T583 | Phosphorylation | Uniprot |
研究背景
Specifically inhibits CDK5 activation by CDK5R1.
Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Forms a complex with CDK5R1 and CDK5.
Belongs to the methylthiotransferase family. MiaB subfamily.
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