AFfirm™ Cytokeratin 2e Mouse Monoclonal Antibody - #BF8605

製品: Cytokeratin 2e Mouse Monoclonal Antibody
カタログ: BF8605
タンパク質の説明: Mouse monoclonal antibody to Cytokeratin 2e
アプリケーション: WB
反応性: Human
予測: Pig, Rabbit, Dog
分子量: 65 kDa; 65kD(Calculated).
ユニプロット: P35908

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IHC Protocol
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製品説明

ソース:
Mouse
アプリケーション:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [AFfirm8605]
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

CK 2e; Cytokeratin-2e; Epithelial keratin-2e; K2e; Keratin type II cytoskeletal 2 epidermal; Keratin-2 epidermis; KRT2; KRT2A; KRT2E; Type-II keratin Kb2;

免疫原

免疫原:

A synthesized peptide derived from human Cytokeratin 2e, corresponding to a region within N-terminal amino acids.

Uniprot:

P35908(K22E_HUMAN) >>Visit HPA database.

遺伝子(ID):
KRT2(3849)
発現特異性:
P35908 K22E_HUMAN:

Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expression in hypertrophic and keloid scars begins in the deepest suprabasal layer. Weakly expressed in normal gingiva and tongue, however expression is induced in benign keratoses of lingual mucosa and in mild-to-moderate oral dysplasia with orthokeratinization.

タンパク質配列:
MSCQISCKSRGRGGGGGGFRGFSSGSAVVSGGSRRSTSSFSCLSRHGGGGGGFGGGGFGSRSLVGLGGTKSISISVAGGGGGFGAAGGFGGRGGGFGGGSSFGGGSGFSGGGFGGGGFGGGRFGGFGGPGGVGGLGGPGGFGPGGYPGGIHEVSVNQSLLQPLNVKVDPEIQNVKAQEREQIKTLNNKFASFIDKVRFLEQQNQVLQTKWELLQQMNVGTRPINLEPIFQGYIDSLKRYLDGLTAERTSQNSELNNMQDLVEDYKKKYEDEINKRTAAENDFVTLKKDVDNAYMIKVELQSKVDLLNQEIEFLKVLYDAEISQIHQSVTDTNVILSMDNSRNLDLDSIIAEVKAQYEEIAQRSKEEAEALYHSKYEELQVTVGRHGDSLKEIKIEISELNRVIQRLQGEIAHVKKQCKNVQDAIADAEQRGEHALKDARNKLNDLEEALQQAKEDLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGDLSSNVTVSVTSSTISSNVASKAAFGGSGGRGSSSGGGYSSGSSSYGSGGRQSGSRGGSGGGGSISGGGYGSGGGSGGRYGSGGGSKGGSISGGGYGSGGGKHSSGGGSRGGSSSGGGYGSGGGGSSSVKGSSGEAFGSSVTFSFR

PTMs - P35908 基板として

Site PTM Type Enzyme
S62 Phosphorylation
S75 Phosphorylation
K183 Ubiquitination
T184 Phosphorylation
K188 Acetylation
K188 Methylation
K188 Sumoylation
K188 Ubiquitination
S191 Phosphorylation
K195 Acetylation
K195 Ubiquitination
Y264 Phosphorylation
K265 Acetylation
K267 Ubiquitination
S347 Phosphorylation
Y356 Phosphorylation
R490 Methylation
R524 Methylation
S526 Phosphorylation
S527 Phosphorylation
S528 Phosphorylation
S536 Phosphorylation
S546 Phosphorylation
S548 Phosphorylation
S557 Phosphorylation
Y563 Phosphorylation
Y573 Phosphorylation
S579 Phosphorylation
S597 Phosphorylation
S598 Phosphorylation
S602 Phosphorylation
S606 Phosphorylation
S607 Phosphorylation
S608 Phosphorylation
S614 Phosphorylation
S620 Phosphorylation
S621 Phosphorylation
T635 Phosphorylation
S637 Phosphorylation

研究背景

機能:

Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity).

組織特異性:

Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expression in hypertrophic and keloid scars begins in the deepest suprabasal layer. Weakly expressed in normal gingiva and tongue, however expression is induced in benign keratoses of lingual mucosa and in mild-to-moderate oral dysplasia with orthokeratinization.

サブユニット構造:

Heterotetramer of two type I and two type II keratins. Associates with KRT10 (By similarity).

タンパク質ファミリー:

Belongs to the intermediate filament family.

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