AFfirm™ Uroplakin III Mouse Monoclonal Antibody - #BF8629

製品: Uroplakin III Mouse Monoclonal Antibody
カタログ: BF8629
タンパク質の説明: Mouse monoclonal antibody to Uroplakin III
アプリケーション: WB
反応性: Human
予測: Mouse
分子量: 31kD(Calculated).
ユニプロット: O75631

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Mouse
アプリケーション:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [AFfirm8629]
特異性:
Uroplakin III Mouse Monoclonal Antibody detects endogenous levels of total Uroplakin III.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

MGC119178; OTTHUMP00000028951; UP III; UP3a; UPIII; UPIIIA; UPK 3; UPK 3A; UPK3; UPK3A; UPK3A_HUMAN; Uroplakin 3A; Uroplakin III; Uroplakin-3a; Uroplakin3A; UroplakinIII;

免疫原

免疫原:

A synthesized peptide derived from Human Uroplakin III.

Uniprot:

O75631(UPK3A_HUMAN) >>Visit HPA database.

遺伝子(ID):
UPK3A(7380)
発現特異性:
O75631 UPK3A_HUMAN:

Expressed in ureter.

タンパク質配列:
MPPLWALLALGCLRFGSAVNLQPQLASVTFATNNPTLTTVALEKPLCMFDSKEALTGTHEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQTEGGRTGPYKAVAFDLIPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFQGLCNAPLSAATEYRFKYVLVNMSTGLVEDQTLWSDPIRTNQLTPYSTIDTWPGRRSGGMIVITSILGSLPFFLLVGFAGAIALSLVDMGSSDGETTHDSQITQEAVPKSLGASESSYTSVNRGPPLDRAEVYSSKLQD

研究背景

機能:

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).

細胞の位置付け:

Endoplasmic reticulum membrane>Single-pass type I membrane protein.
Note: Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in ureter.

サブユニット構造:

Heterodimer with uroplakin-1B (UPK1B).

タンパク質ファミリー:

Belongs to the uroplakin-3 family.

研究領域

· Human Diseases > Cancers: Specific types > Bladder cancer.   (View pathway)

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