AFfirm™ ORC6L Mouse Monoclonal Antibody - #BF8636
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
ORC 6; Orc6; ORC6_HUMAN; ORC6L; Origin recognition complex subunit 6; origin recognition complex subunit 6 homolog like; origin recognition complex subunit 6 homolog like (yeast); origin recognition complex subunit 6 like (yeast);
免疫原
- Q9Y5N6 ORC6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGSELIGRLAPRLGLAEPDMLRKAEEYLRLSRVKCVGLSARTTETSSAVMCLDLAASWMKCPLDRAYLIKLSGLNKETYQSCLKSFECLLGLNSNIGIRDLAVQFSCIEAVNMASKILKSYESSLPQTQQVDLDLSRPLFTSAALLSACKILKLKVDKNKMVATSGVKKAIFDRLCKQLEKIGQQVDREPGDVATPPRKRKKIVVEAPAKEMEKVEEMPHKPQKDEDLTQDYEEWKRKILENAASAQKATAE
PTMs - Q9Y5N6 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K23 | Ubiquitination | Uniprot | |
| K34 | Ubiquitination | Uniprot | |
| R65 | Methylation | Uniprot | |
| Y67 | Phosphorylation | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| K76 | Ubiquitination | Uniprot | |
| T78 | Phosphorylation | Uniprot | |
| Y79 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| K119 | Ubiquitination | Uniprot | |
| K168 | Acetylation | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| T195 | Phosphorylation | P06493 (CDK1) | Uniprot |
| K202 | Ubiquitination | Uniprot | |
| K210 | Acetylation | Uniprot | |
| K210 | Ubiquitination | Uniprot | |
| K214 | Acetylation | Uniprot | |
| K221 | Acetylation | Uniprot | |
| T229 | Phosphorylation | Uniprot | |
| Y232 | Phosphorylation | Uniprot | |
| K236 | Ubiquitination | Uniprot | |
| K238 | Ubiquitination | Uniprot | |
| S245 | Phosphorylation | Uniprot | |
| K248 | Ubiquitination | Uniprot |
研究背景
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Nucleus.
Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4 (By similarity).
Belongs to the ORC6 family.
研究領域
· Cellular Processes > Cell growth and death > Cell cycle. (View pathway)
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