AFfirm™ INPP5E Mouse Monoclonal Antibody - #BF8637
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
5-bisphosphate 5-phosphatase; 72 kDa inositol polyphosphate 5-phosphatase; Inositol polyphosphate 5 phosphatase; INP5E_HUMAN; Inpp5e; Phosphatidylinositol (4,5) bisphosphate 5 phosphatase; Phosphatidylinositol 4; Phosphatidylinositol polyphosphate 5 phosphatase type IV; Phosphatidylinositol polyphosphate 5-phosphatase type IV; PPI5PIV;
免疫原
- Q9NRR6 INP5E_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPSKAENLRPSEPAPQPPEGRTLQGQLPGAPPAQRAGSPPDAPGSESPALACSTPATPSGEDPPARAAPIAPRPPARPRLERALSLDDKGWRRRRFRGSQEDLEARNGTSPSRGSVQSEGPGAPAHSCSPPCLSTSLQEIPKSRGVLSSERGSPSSGGNPLSGVASSSPNLPHRDAAVAGSSPRLPSLLPPRPPPALSLDIASDSLRTANKVDSDLADYKLRAQPLLVRAHSSLGPGRPRSPLACDDCSLRSAKSSFSLLAPIRSKDVRSRSYLEGSLLASGALLGADELARYFPDRNVALFVATWNMQGQKELPPSLDEFLLPAEADYAQDLYVIGVQEGCSDRREWETRLQETLGPHYVLLSSAAHGVLYMSLFIRRDLIWFCSEVECSTVTTRIVSQIKTKGALGISFTFFGTSFLFITSHFTSGDGKVAERLLDYTRTVQALVLPRNVPDTNPYRSSAADVTTRFDEVFWFGDFNFRLSGGRTVVDALLCQGLVVDVPALLQHDQLIREMRKGSIFKGFQEPDIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYRSRHKGDICPVSYSSCPGIKTSDHRPVYGLFRVKVRPGRDNIPLAAGKFDRELYLLGIKRRISKEIQRQQALQSQNSSTICSVS
PTMs - Q9NRR6 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S38 | Phosphorylation | Uniprot | |
| S85 | Phosphorylation | Uniprot | |
| S99 | Phosphorylation | Uniprot | |
| T109 | Phosphorylation | Uniprot | |
| S153 | Phosphorylation | Uniprot | |
| S156 | Phosphorylation | Uniprot | |
| S166 | Phosphorylation | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| S241 | Phosphorylation | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| S255 | Phosphorylation | Uniprot | |
| Y293 | Phosphorylation | Uniprot | |
| Y439 | Phosphorylation | Uniprot | |
| T455 | Phosphorylation | Uniprot | |
| K521 | Ubiquitination | Uniprot | |
| T542 | Phosphorylation | Uniprot | |
| K565 | Ubiquitination | Uniprot |
研究背景
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Specific for lipid substrates, inactive towards water soluble inositol phosphates. Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity).
Cytoplasm>Cytoskeleton>Cilium axoneme. Golgi apparatus>Golgi stack membrane>Peripheral membrane protein>Cytoplasmic side. Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cell projection>Ruffle. Cytoplasm.
Note: Peripheral membrane protein associated with Golgi stacks.
Detected in brain, heart, pancreas, testis and spleen.
Interacts (when prenylated) with PDE6D; this is important for normal location in cilia.
Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type IV family.
研究領域
· Environmental Information Processing > Signal transduction > Phosphatidylinositol signaling system.
· Metabolism > Carbohydrate metabolism > Inositol phosphate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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