AFfirm™ ANGPT4 Mouse Monoclonal Antibody - #BF8642

製品: ANGPT4 Mouse Monoclonal Antibody
カタログ: BF8642
タンパク質の説明: Mouse monoclonal antibody to ANGPT4
アプリケーション: WB
反応性: Human
予測: Mouse, Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
分子量: 57 kDa; 57kD(Calculated).
ユニプロット: Q9Y264

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 100ul $280 在庫あり
 200ul $350 在庫あり

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関連ダウンロード
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Mouse
アプリケーション:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [AFfirm8642]
特異性:
ANGPT4 Mouse Monoclonal Antibody detects endogenous levels of total ANGPT4.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

AGP4; ANG-3; ANG-4; ANG3; ANG4; Angiopoietin 3; Angiopoietin 4; Angiopoietin-3; Angiopoietin-4; ANGP4_HUMAN; ANGPT4; dJ824F16.2 (angiopoietin 4); MGC138181; MGC138183; OTTHUMP00000029947;

免疫原

免疫原:
Uniprot:

Q9Y264(ANGP4_HUMAN) >>Visit HPA database.

遺伝子(ID):
ANGPT4(51378)
発現特異性:
Q9Y264 ANGP4_HUMAN:

Highly expressed in the lung with much lower levels found in other tissues.

タンパク質配列:
MLSQLAMLQGSLLLVVATMSVAQQTRQEADRGCETLVVQHGHCSYTFLLPKSEPCPPGPEVSRDSNTLQRESLANPLHLGKLPTQQVKQLEQALQNNTQWLKKLERAIKTILRSKLEQVQQQMAQNQTAPMLELGTSLLNQTTAQIRKLTDMEAQLLNQTSRMDAQMPETFLSTNKLENQLLLQRQKLQQLQGQNSALEKRLQALETKQQEELASILSKKAKLLNTLSRQSAALTNIERGLRGVRHNSSLLQDQQHSLRQLLVLLRHLVQERANASAPAFIMAGEQVFQDCAEIQRSGASASGVYTIQVSNATKPRKVFCDLQSSGGRWTLIQRRENGTVNFQRNWKDYKQGFGDPAGEHWLGNEVVHQLTRRAAYSLRVELQDWEGHEAYAQYEHFHLGSENQLYRLSVVGYSGSAGRQSSLVLQNTSFSTLDSDNDHCLCKCAQVMSGGWWFDACGLSNLNGVYYHAPDNKYKMDGIRWHYFKGPSYSLRASRMMIRPLDI

PTMs - Q9Y264 基板として

Site PTM Type Enzyme
S72 Phosphorylation
T150 Phosphorylation
T226 Phosphorylation
S228 Phosphorylation

研究背景

機能:

Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Highly expressed in the lung with much lower levels found in other tissues.

サブユニット構造:

Homodimer; disulfide-linked. Interacts with TEK/TIE2.

研究領域

· Environmental Information Processing > Signal transduction > MAPK signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Ras signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Rap1 signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > HIF-1 signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

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