AFfirm™ SCNM1 Mouse Monoclonal Antibody - #BF8652
製品説明
ソース:
Mouse
アプリケーション:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
反応性:
Human
クローナリティ:
Monoclonal [AFfirm8652]
特異性:
SCNM1 Mouse Monoclonal Antibody detects endogenous levels of total SCNM1.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:
折りたたみ／展開
SCNM 1; Sodium channel modifier 1;
免疫原
免疫原:
Uniprot:
遺伝子(ID):
タンパク質配列:
- Q9BWG6 SCNM1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLQLFYGKKQPGKERKQNPKHQNELRREETKAEAPLLTQTRLITQSALHRAPHYNSCCRRKYRPEAPGPSVSLSPMPPSEVKLQSGKISREPEPAAGPQAEESATVSAPAPMSPTRRRALDHYLTLRSSGWIPDGRGRWVKDENVEFDSDEEEPPDLPLD
PTMs - Q9BWG6 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| K17 | Ubiquitination | Uniprot | |
| Y76 | Phosphorylation | Uniprot | |
| K101 | Ubiquitination | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| S144 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| S183 | Phosphorylation | Uniprot | |
| Y193 | Phosphorylation | Uniprot | |
| T195 | Phosphorylation | Uniprot | |
| S219 | Phosphorylation | Uniprot |
研究背景
機能:
Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.
細胞の位置付け:
Nucleus>Nucleoplasm. Nucleus speckle.
Note: Colocalizes with LUC7L2 and SNRNP70 in nuclear speckles.
サブユニット構造:
Interacts with spliceosomal Sm proteins. Interacts with LUC7L2 and SNRNP70, which suggests a role as a spliceosome component (By similarity).
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For Research Use Only.
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